التفاصيل البيبلوغرافية
| العنوان: |
What Is the Trait d’Union between Retroactivity and Molecular Communication Performance Limits? |
| المؤلفون: |
Francesca Ratti, Maurizio Magarini, Domitilla Del Vecchio |
| المصدر: |
Molecules; Volume 27; Issue 10; Pages: 3130 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
molecular communication, mutual information, systems biology, synthetic biology, communication systems, retroactivity |
| جغرافية الموضوع: |
agris |
| الوصف: |
Information exchange is a critical process in all communication systems, including biological ones. Retroactivity describes the load that downstream modules apply to their upstream systems in biological circuits. The motivation behind this work is that of integrating retroactivity, a concept proper of biochemical circuits, with the metrics defined in Information Theory and Digital Communications. This paper focuses on studying the impact of retroactivity on different biological signaling system models, which present analogies with well-known telecommunication systems. The mathematical analysis is performed both in the high and low molecular counts regime, by mean of the Chemical Master Equation and the Linear Noise Approximation, respectively. The main goal of this work is to provide analytical tools to maximize the reliable information exchange across different biomolecular circuit models. Results highlight how, in general, retroactivity harms communication performance. This negative effect can be mitigated by adding to the signaling circuit an independent upstream system that connects with the same pool of downstream circuits. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Bioorganic Chemistry; https://dx.doi.org/10.3390/molecules27103130 |
| DOI: |
10.3390/molecules27103130 |
| الاتاحة: |
https://doi.org/10.3390/molecules27103130 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.F5DF50E9 |
| قاعدة البيانات: |
BASE |