Academic Journal
Intravenous immunoglobulin to treat neonatal alloimmune haemolytic disease.
| العنوان: | Intravenous immunoglobulin to treat neonatal alloimmune haemolytic disease. |
|---|---|
| المؤلفون: | CORVAGLIA, LUIGI TOMMASO, GALLETTI, SILVIA, ARCURI, SANTO, ACETI, ARIANNA, FALDELLA, GIACOMO, Legnani E |
| المساهمون: | Corvaglia L, Legnani E, Galletti S, Arcuri S, Aceti A, Faldella G. |
| سنة النشر: | 2012 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Exchange transfusion, intravenous immunoglobulin, newborn, rhesus haemolytic disease |
| الوصف: | OBJECTIVE: To compare the efficacy of intravenous immunoglobulin (IVIg) and exchange transfusion (EXT) on rhesus haemolytic disease of the newborn (Rh-HDN) and evaluate treatment-related side effects. METHODS: Retrospective chart review of two cohorts of newborns with Rh-HDN, treated with (Group 2) or without (Group 1) IVIg. Length of phototherapy, number of EXT, IVIg infusions, intrauterine and top-up red blood cells transfusions, need and permanence of umbilical venous catheter, and length of hospital stay, as well as treatment-related adverse events, were evaluated. RESULTS: Charts of 88 newborns were reviewed (34 in Group 1, 54 in Group 2). Infants in Group 2 received a significantly lower number of EXT, had a lower risk of neurological impairment and needed an umbilical venous catheter for shorter, but required longer phototherapy, longer length of hospital stay, and more top-up transfusions. EXT was associated with a high number of adverse events. Two newborns treated with IVIg developed necrotizing enterocolitis (NEC). CONCLUSIONS: IVIg appear as an effective alternative to EXT, reducing the risk of neurological impairment and complications related to EXT. However, side effects of IVIg treatment (higher need of top-up transfusions and longer hospital stay) should be taken into account and the risk of NEC should be carefully monitored during treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/22882154; info:eu-repo/semantics/altIdentifier/wos/WOS:000311678300066; volume:25; issue:12; firstpage:2782; lastpage:2785; numberofpages:4; journal:THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE; http://hdl.handle.net/11585/126022; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84870345901 |
| DOI: | 10.3109/14767058.2012.718387 |
| الاتاحة: | http://hdl.handle.net/11585/126022 https://doi.org/10.3109/14767058.2012.718387 |
| رقم الانضمام: | edsbas.F5C8701B |
| قاعدة البيانات: | BASE |
| DOI: | 10.3109/14767058.2012.718387 |
|---|