Academic Journal
Toronto workshop on late recurrence in estrogen receptor-positive breast cancer: Part 1: Late Recurrence: Current understanding, clinical considerations
| العنوان: | Toronto workshop on late recurrence in estrogen receptor-positive breast cancer: Part 1: Late Recurrence: Current understanding, clinical considerations |
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| المؤلفون: | Dowling, R.J.O., Kalinsky, K., Hayes, D.F., Bidard, F.-C., Cescon, D.W., Chandarlapaty, S., Deasy, J.O., Dowsett, M., Gray, R.J., Henry, N.L., Meric-Bernstam, F., Perlmutter, J., Sledge, G.W., Bratman, S.V., Carey, L.A., Chang, M.C., DeMichele, A., Ennis, M., Jerzak, K.J., Korde, L.A., Lohmann, A.E, Mamounas, E.P., Parulekar, W.R., Regan, M.M., Schramek, D., Stambolic, V., Thorat, M.A., Whelan, T.J., Wolff, A.C., Woodgett, J.R., Sparano, J.A., Goodwin, P.J. |
| المصدر: | JNCI Cancer Spectrum, 3(4) |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2019 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | bisphosphonic acid derivative, cancer surgery, estrogen receptor positive breast cancer, tamoxifen, clinical feature, lifestyle modification, recurrence risk, serology, diagnostic test, aromatase inhibitor, immunopathology, early cancer, cancer hormone therapy, comorbidity, hydroxymethylglutaryl coenzyme A reductase inhibitor, tibolone, cancer patient, Review, breast reconstruction, human, risk factor, cancer recurrence |
| الوصف: | Disease recurrence (locoregional, distant) exerts a significant clinical impact on the survival of estrogen receptor-positive breast cancer patients. Many of these recurrences occur late, more than 5 years after original diagnosis, and represent a major obstacle to the effective treatment of this disease. Indeed, methods to identify patients at risk of late recurrence and therapeutic strategies designed to avert or treat these recurrences are lacking. Therefore, an international workshop was convened in Toronto, Canada, in February 2018 to review the current understanding of late recurrence and to identify critical issues that require future study. In this article, the major issues surrounding late recurrence are defined and current approaches that may be applicable to this challenge are discussed. Specifically, diagnostic tests with potential utility in late-recurrence prediction are described as well as a variety of patient-related factors that may influence recurrence risk. Clinical and therapeutic approaches are also reviewed, with a focus on patient surveillance and the implementation of extended endocrine therapy in the context of late-recurrence prevention. Understanding and treating late recurrence in estrogen receptor-positive breast cancer is a major unmet clinical need. A concerted effort of basic and clinical research is required to confront late recurrence and improve disease management and patient survival. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://cdr.lib.unc.edu/downloads/9880w148j?file=thumbnail; https://cdr.lib.unc.edu/downloads/9880w148j |
| DOI: | 10.17615/bxz4-9580 |
| الاتاحة: | https://doi.org/10.17615/bxz4-9580 https://cdr.lib.unc.edu/downloads/9880w148j?file=thumbnail https://cdr.lib.unc.edu/downloads/9880w148j |
| Rights: | http://rightsstatements.org/vocab/InC/1.0/ |
| رقم الانضمام: | edsbas.F5A5D635 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/bxz4-9580 |
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