Academic Journal
Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome ; A case report
| العنوان: | Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome ; A case report |
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| المؤلفون: | Asano, Tomoyuki, Furuya, Makiko Yashiro, Fujita, Yuya, Matsuoka, Naoki, Sato, Shuzo, Kobayashi, Hiroko, Watanabe, Hiroshi, Honda, Aki, Migita, Kiyoshi |
| المصدر: | Medicine ; volume 97, issue 41, page e12725 ; ISSN 0025-7974 1536-5964 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2018 |
| الوصف: | Rationale: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare condition that affects the skin, bones, and joints. Diagnosis of SAPHO syndrome is established based on clinical manifestations and imaging features on radiography or magnetic resonance imaging. Patient concerns: We report a 44-year-old male with a 20-year history of pustulosis who presented with pain in the lower extremities. Plain radiography demonstrated hyperostosis with subperiosteal erosions in the right tibia. Magnetic resonance imaging and computed tomography showed inflammatory accumulation, whereas musculoskeletal ultrasonography clearly depicted a periosteal reaction, osteitis, and enthesitis with abnormal blood flow in the surface of the right tibia. Diagnoses: A diagnosis of SAPHO syndrome was made. Interventions: The patient was treated with combination therapy comprising prednisolone, methotrexate, and infliximab, which resulted in clinical improvement. Outcomes: The elevated levels of C-reactive protein and matrix metalloproteinase-3 normalized, and the abnormal ultrasonographic findings disappeared. Lessons: The present case report demonstrates that multiple imaging modalities are important for the definitive diagnosis of SAPHO syndrome. Ultrasonography might be a useful tool for evaluating local musculoskeletal inflammation in patients with SAPHO syndrome. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/md.0000000000012725 |
| الاتاحة: | http://dx.doi.org/10.1097/md.0000000000012725 https://journals.lww.com/00005792-201810120-00054 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0 |
| رقم الانضمام: | edsbas.F5A32F7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/md.0000000000012725 |
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