Academic Journal
Initially Lymphocytic Sweet's Syndrome in Male Patients with Myelodysplasia: A Distinguished Clinicopathological Entity? Case Report and Systematic Review of the Literature
| العنوان: | Initially Lymphocytic Sweet's Syndrome in Male Patients with Myelodysplasia: A Distinguished Clinicopathological Entity? Case Report and Systematic Review of the Literature |
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| المؤلفون: | Kakaletsis, Nikolaos, Kaiafa, Georgia, Savopoulos, Christos, Iliadis, Fotios, Perifanis, Vasilios, Tzalokostas, Vasilios, Grekou, Alexandra, Giannouli, Angeliki, Hatzitolios, Apostolos I. |
| المصدر: | Acta Haematologica ; volume 132, issue 2, page 220-225 ; ISSN 0001-5792 1421-9662 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2014 |
| الوصف: | Background: Sweet's syndrome (SS) is an acute febrile neutrophilic dermatosis. It can occur as an idiopathic, drug-induced or malignancy-associated entity. SS is also seen in patients with myelodysplastic syndrome (MDS) where it may present atypically, both clinically and histologically. In a few rare cases of MDS, lymphocytic infiltrates are the presenting feature of SS. Methods: MEDLINE and Scopus were the data sources for our review. Results: A clinicopathological subset emerged of 12 male SS patients with MDS and a mean age of 67.3 years in which the initial SS lesions were lymphocytic infiltrates. However, from 0.5 to 8 years later, sequential biopsies revealed neutrophilic dermal infiltration typical of SS. Conclusion: Initially lymphocytic infiltrates in this subset could be attributed either to an early timing of the biopsy concerning the age of the lesion or to the dysgranulopoiesis syndrome. A possible relationship between the dysfunction of the receptor of the granulocyte-macrophage colony stimulating factor, the gene of which is located on the pseudoautosomal X-Y region, may exist in MDS patients with initially lymphocytic SS. This could explain the male gender of this subset and might establish initially lymphocytic SS as a distinguished clinicopathological entity for predicting the occurrence and even the prognosis of MDS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000357933 |
| الاتاحة: | http://dx.doi.org/10.1159/000357933 https://www.karger.com/Article/Pdf/357933 |
| Rights: | https://www.karger.com/Services/SiteLicenses ; https://www.karger.com/Services/SiteLicenses |
| رقم الانضمام: | edsbas.F5985FC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000357933 |
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