Academic Journal
Toxic Peripheral Neuropathies: Agents and Mechanisms
| العنوان: | Toxic Peripheral Neuropathies: Agents and Mechanisms |
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| المؤلفون: | Valentine, William M. |
| المساهمون: | National Institute of Environmental Health Sciences |
| المصدر: | Toxicologic Pathology ; volume 48, issue 1, page 152-173 ; ISSN 0192-6233 1533-1601 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2019 |
| الوصف: | Toxic peripheral neuropathies are an important form of acquired polyneuropathy produced by a variety of xenobiotics and different exposure scenarios. Delineating the mechanisms of neurotoxicants and determining the degenerative biological pathways triggered by peripheral neurotoxicants will facilitate the development of sensitive and specific biochemical-based methods for identifying neurotoxicants, designing therapeutic interventions, and developing structure–activity relationships for predicting potential neurotoxicants. This review presents an overview of the general concepts of toxic peripheral neuropathies with the goal of providing insight into why certain agents target the peripheral nervous system and produce their associated lesions. Experimental data and the main hypotheses for the mechanisms of selected agents that produce neuronopathies, axonopathies, or myelinopathies including covalent or noncovalent modifications, compromised energy or protein biosynthesis, and oxidative injury and disruption of ionic gradients across membranes are presented. The relevance of signaling between the main components of peripheral nerve, that is, glia, neuronal perikaryon, and axon, as a target for neurotoxicants and the contribution of active programmed degenerative pathways to the lesions observed in toxic peripheral neuropathies is also discussed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/0192623319854326 |
| الاتاحة: | https://doi.org/10.1177/0192623319854326 https://journals.sagepub.com/doi/pdf/10.1177/0192623319854326 https://journals.sagepub.com/doi/full-xml/10.1177/0192623319854326 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.F57A2CBF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/0192623319854326 |
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