Academic Journal
Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis
| العنوان: | Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis |
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| المؤلفون: | Hasanaj, Arbi, Zaki, Faaris, Harman, Karen E., Grindlay, Douglas, Gran, S. |
| سنة النشر: | 2021 |
| المجموعة: | University of Nottingham: Repository@Nottingham |
| مصطلحات موضوعية: | Centre of Evidence Based Dermatology |
| الوصف: | Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are autoimmune blistering skin disorders which are increasing in incidence and are associated with high mortality. 1,2 As people with BP and PV often have comorbidity and require treatment that has severe side-effects, they could die of various causes. 3,4,5 A systematic review on cause-specific mortality in has not previously been conducted. The aim of this study was to examine causes of death in patients with BP and PV. The study protocol was registered with PROSPERO (CRD42020202620); PRISMA guidelines were followed. On 10 th October 2020, a search was conducted in MEDLINE, Embase and Cochrane Central Register of Controlled Trials. Grey literature was identified using the EthOs library and OpenGrey. Randomised control trials (RCTS) and cohort studies were included due to follow-up being integrated within the study designs. To be included, studies had to report at least one measure of cause-specific mortality in people with BP or PV. All languages were included. Three authors performed independent study screening, data extraction and quality assessment, using the Joanna Briggs Institute tool for cohort studies. 6 Disparities were resolved by discussion. We defined high-quality studies as those with at least one-year of follow-up and a control group matched for age and gender as these criteria minimise bias and confounding. For each study, the proportional mortality (PM) was calculated by dividing the number of deaths from a specific cause by the total number of deaths. The standardised mortality ratio (SMR) was calculated by observed deaths divided by expected deaths of the reference population. Meta-analyses were conducted using a Der Simonian-Lairds random-effects model, determining (i) the pooled PM and, (ii) the pooled SMR for causes of death where available. 7 Subgroup analysis was not carried out due to insufficient data. Heterogeneity was assessed using I 2 (>75% defined as considerable heterogeneity). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0007-0963 |
| Relation: | https://nottingham-repository.worktribe.com/output/6344180; British Journal of Dermatology; Volume 186; Issue 2; Pagination 359-361; https://nottingham-repository.worktribe.com/file/6344180/1/Gran%20Manuscript%20Clean%20R2 |
| DOI: | 10.1111/bjd.20759 |
| الاتاحة: | https://doi.org/10.1111/bjd.20759 https://nottingham-repository.worktribe.com/file/6344180/1/Gran%20Manuscript%20Clean%20R2 https://nottingham-repository.worktribe.com/output/6344180 |
| Rights: | openAccess |
| رقم الانضمام: | edsbas.F561B62E |
| قاعدة البيانات: | BASE |
| تدمد: | 00070963 |
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| DOI: | 10.1111/bjd.20759 |