Academic Journal
Molecular and Genetic Biomarkers in Idiopathic Pulmonary Fibrosis: Where Are We Now?
| العنوان: | Molecular and Genetic Biomarkers in Idiopathic Pulmonary Fibrosis: Where Are We Now? |
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| المؤلفون: | Ioannis Tomos, Ioannis Roussis, Andreas M. Matthaiou, Katerina Dimakou |
| المصدر: | Biomedicines, Vol 11, Iss 2796, p 2796 (2023) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | idiopathic pulmonary fibrosis, acute exacerbation of idiopathic pulmonary fibrosis, molecular biomarkers, genetics, diagnostic, prognostic role, Biology (General), QH301-705.5 |
| الوصف: | Idiopathic pulmonary fibrosis (IPF) represents a chronic progressive fibrotic interstitial lung disease of unknown cause with an ominous prognosis. It remains an unprecedent clinical challenge due to its delayed diagnosis and unpredictable clinical course. The need for accurate diagnostic, prognostic and predisposition biomarkers in everyday clinical practice becomes more necessary than ever to ensure prompt diagnoses and early treatment. The identification of such blood biomarkers may also unravel novel drug targets against IPF development and progression. So far, the role of diverse blood biomarkers, implicated in various pathogenetic pathways, such as in fibrogenesis (S100A4), extracellular matrix remodelling (YKL-40, MMP-7, ICAM-1, LOXL2, periostin), chemotaxis (CCL-18, IL-8), epithelial cell injury (KL-6, SP-A, SP-D), autophagy and unfolded protein response has been investigated in IPF with various results. Moreover, the recent progress in genetics in IPF allows for a better understanding of the underlying disease mechanisms. So far, the causative mutations in pulmonary fibrosis include mutations in telomere-related genes and in surfactant-related genes, markers that could act as predisposition biomarkers in IPF. The aim of this review is to provide a comprehensive overview from the bench to bedside of current knowledge and recent insights on biomarkers in IPF, and to suggest future directions for research. Large-scale studies are still needed to confirm the exact role of these biomarkers. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2227-9059 |
| Relation: | https://www.mdpi.com/2227-9059/11/10/2796; https://doaj.org/toc/2227-9059; https://doaj.org/article/592228c197784270a19a4ee76810689f |
| DOI: | 10.3390/biomedicines11102796 |
| الاتاحة: | https://doi.org/10.3390/biomedicines11102796 https://doaj.org/article/592228c197784270a19a4ee76810689f |
| رقم الانضمام: | edsbas.F55A27F3 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22279059 |
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| DOI: | 10.3390/biomedicines11102796 |