Academic Journal
Abdominal imaging associates body composition with COVID-19 severity
| العنوان: | Abdominal imaging associates body composition with COVID-19 severity |
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| المؤلفون: | Basty, N., Sorokin, E., Thanaj, M., Srinivasan, R., Whitcher, B., Bell, J.D., Cule, M., Thomas, E.L. |
| بيانات النشر: | PLoS |
| سنة النشر: | 2023 |
| المجموعة: | University of Westminster: WestminsterResearch |
| الوصف: | The main drivers of COVID-19 disease severity and the impact of COVID-19 on long-term health after recovery are yet to be fully understood. Medical imaging studies investigating COVID-19 to date have mostly been limited to small datasets and post-hoc analyses of severe cases. The UK Biobank recruited recovered SARS-CoV-2 positive individuals (n = 967) and matched controls (n = 913) who were extensively imaged prior to the pandemic and underwent follow-up scanning. In this study, we investigated longitudinal changes in body composition, as well as the associations of pre-pandemic image-derived phenotypes with COVID-19 severity. Our longitudinal analysis, in a population of mostly mild cases, associated a decrease in lung volume with SARS-CoV-2 positivity. We also observed that increased visceral adipose tissue and liver fat, and reduced muscle volume, prior to COVID-19, were associated with COVID-19 disease severity. Finally, we trained a machine classifier with demographic, anthropometric and imaging traits, and showed that visceral fat, liver fat and muscle volume have prognostic value for COVID-19 disease severity beyond the standard demographic and anthropometric measurements. This combination of image-derived phenotypes from abdominal MRI scans and ensemble learning to predict risk may have future clinical utility in identifying populations at-risk for a severe COVID-19 outcome. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | https://westminsterresearch.westminster.ac.uk/download/7c7b0e869b8318654929e3c334fd6f3467f8f4dadac9e6276b381aa9c7da7b27/1684947/journal.pone.0283506.pdf; https://doi.org/10.1371/journal.pone.0283506; Basty, N., Sorokin, E., Thanaj, M., Srinivasan, R., Whitcher, B., Bell, J.D., Cule, M. and Thomas, E.L. 2023. Abdominal imaging associates body composition with COVID-19 severity. PLoS ONE. 18 (4) e0283506. https://doi.org/10.1371/journal.pone.0283506 |
| DOI: | 10.1371/journal.pone.0283506 |
| الاتاحة: | https://westminsterresearch.westminster.ac.uk/item/w27vx/abdominal-imaging-associates-body-composition-with-covid-19-severity https://westminsterresearch.westminster.ac.uk/download/7c7b0e869b8318654929e3c334fd6f3467f8f4dadac9e6276b381aa9c7da7b27/1684947/journal.pone.0283506.pdf https://doi.org/10.1371/journal.pone.0283506 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.F54E881 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0283506 |
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