Academic Journal
The association of hemoglobin drop with in-hospital outcomes in COVID-19 patients
| العنوان: | The association of hemoglobin drop with in-hospital outcomes in COVID-19 patients |
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| المؤلفون: | Kuno, T, Miyamoto, Y, Iwagami, M, Ishimaru, M, So, M, Takahashi, M, Egorova, N N |
| المصدر: | QJM: An International Journal of Medicine ; volume 114, issue 11, page 789-794 ; ISSN 1460-2725 1460-2393 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2021 |
| الوصف: | Background Bleeding events can be critical in hospitalized patients with COVID-19, especially those with aggressive anticoagulation therapy. Aim We aimed to investigate whether hemoglobin drop was associated with increased risk of acute kidney injury (AKI) and in-hospital mortality among patients with COVID-19. Design Retrospective cohort study. Methods This retrospective study was conducted by review of the medical records of 6683 patients with laboratory-confirmed COVID-19 hospitalized in the Mount Sinai Health system between 1st March 2020 and 30th March 2021. We compared patients with and without hemoglobin drop >3 g/dl during hospitalization within a week after admissions, using inverse probability treatment weighted analysis (IPTW). Outcomes of interest were in-hospital mortality and AKI which was defined as serum creatine change of 0.3 mg/dl increase or 1.5 times baseline. Results Of the 6683 patients admitted due to COVID-19, 750 (11.2%) patients presented with a marked hemoglobin drop. Patients with hemoglobin drop were more likely to receive therapeutic anticoagulation within 2 days after admissions. Patients with hemoglobin drop had higher crude in-hospital mortality (40.8% vs. 20.0%, P < 0.001) as well as AKI (51.4% vs. 23.9%, P < 0.001) compared to those without. IPTW analysis showed that hemoglobin drop was associated with higher in-hospital mortality compared to those without (odds ratio (OR) [95% confidential interval (CI)]: 2.21 [1.54–2.88], P < 0.001) as well as AKI (OR [95% CI]: 2.79 [2.08–3.73], P < 0.001). Conclusions Hemoglobin drop during COVID-19 related hospitalizations was associated with a higher risk of AKI and in-hospital mortality. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/qjmed/hcab251 |
| DOI: | 10.1093/qjmed/hcab251/40548886/hcab251.pdf |
| الاتاحة: | http://dx.doi.org/10.1093/qjmed/hcab251 http://academic.oup.com/qjmed/advance-article-pdf/doi/10.1093/qjmed/hcab251/40548886/hcab251.pdf https://academic.oup.com/qjmed/article-pdf/114/11/789/42079728/hcab251.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| رقم الانضمام: | edsbas.F52D4B0A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/qjmed/hcab251 |
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