Academic Journal
Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform
| العنوان: | Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform |
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| المؤلفون: | Whyte, William, Goswami, Debkalpa, Wang, Sophie X., Fan, Yiling, Ward, Niamh A., Levey, Ruth E., Beatty, Rachel, Robinson, Scott T., Sheppard, Declan, O’Connor, Raymond, Monahan, David S., Trask, Lesley, Mendez, Keegan L., Varela, Claudia E., Horvath, Markus A., Wylie, Robert, O’Dwyer, Joanne, Domingo-Lopez, Daniel A., Rothman, Arielle S., Duffy, Garry P., Dolan, Eimear B., Roche, Ellen T. |
| المساهمون: | Science Foundation Ireland, Horizon 2020 |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2023 |
| المجموعة: | National University of Ireland (NUI), Galway: ARAN |
| مصطلحات موضوعية: | Dynamic actuation, therapeutic lifespan, implantable drug delivery platform, Biomedical engineering, Drug delivery, Implants |
| الوصف: | Fibrous capsule (FC) formation, secondary to the foreign body response (FBR), impedes molecular transport and is detrimental to the long-term efficacy of implantable drug delivery devices, especially when tunable, temporal control is necessary. We report the development of an implantable mechanotherapeutic drug delivery platform to mitigate and overcome this host immune response using two distinct, yet synergistic soft robotic strategies. Firstly, daily intermittent actuation (cycling at 1¿Hz for 5¿minutes every 12¿hours) preserves long-term, rapid delivery of a model drug (insulin) over 8 weeks of implantation, by mediating local immunomodulation of the cellular FBR and inducing multiphasic temporal FC changes. Secondly, actuation-mediated rapid release of therapy can enhance mass transport and therapeutic effect with tunable, temporal control. In a step towards clinical translation, we utilise a minimally invasive percutaneous approach to implant a scaled-up device in a human cadaveric model. Our soft actuatable platform has potential clinical utility for a variety of indications where transport is affected by fibrosis, such as the management of type 1 diabetes. ; W.W., S.T.R., R.B., and G.P.D. acknowledge support from Science Foundation Ireland under grant SFI/12/RC/2278, Advanced Materials and Bioengineering Research (AMBER) Centre, Royal College of Surgeons in Ireland, National University of Ireland Galway, and Trinity College Dublin, Ireland. W.W., E.B.D., and E.T.R. acknowledge a Pilot and Feasibility Grant from the Juvenile Diabetes Research Fund (1-PNF-2019-778-S-B). N.A.W. and E.B.D. acknowledge funding from the Science Foundation Ireland Royal Society University Research Fellowship (URF\R1\191335). S.X.W. acknowledges funding from the National Institutes of Health training grant T32 HL007734. S.T.R. has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Actions Grant Agreement No. 713567. D.S.M. acknowledges funding from the Irish ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| Relation: | Nature Communications; Whyte, William, Goswami, Debkalpa, Wang, Sophie X., Fan, Yiling, Ward, Niamh A., Levey, Ruth E., Beatty, Rachel, Robinson, Scott T., Sheppard, Declan, O’Connor, Raymond, Monahan, David S., Trask, Lesley, Mendez, Keegan L., Varela, Claudia E., Horvath, Markus A., Wylie, Robert, O’Dwyer, Joanne, Domingo-Lopez, Daniel A., Rothman, Arielle S., Duffy, Garry P., Dolan, Eimear B., Roche, Ellen T. (2022). Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform. Nature Communications, 13(1), 4496. doi:10.1038/s41467-022-32147-w; http://hdl.handle.net/10379/17745 |
| DOI: | 10.1038/s41467-022-32147-w |
| الاتاحة: | http://hdl.handle.net/10379/17745 https://doi.org/10.1038/s41467-022-32147-w |
| Rights: | Attribution 4.0 International (CC BY 4.0) ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.F4EFCF07 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-022-32147-w |