Academic Journal
Nonalcoholic Fatty Liver Disease:Rapid Evaluation of Liver Fat Content with In-Phase and Out-of-Phase MR Imaging
| العنوان: | Nonalcoholic Fatty Liver Disease:Rapid Evaluation of Liver Fat Content with In-Phase and Out-of-Phase MR Imaging |
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| المؤلفون: | Borra, Ronald J. H., Salo, Sakari, Dean, Kirsti, Lautamaki, Riikka, Nuutila, Pirjo, Komu, Markku, Parkkola, Riitta |
| المصدر: | Borra , R J H , Salo , S , Dean , K , Lautamaki , R , Nuutila , P , Komu , M & Parkkola , R 2009 , ' Nonalcoholic Fatty Liver Disease : Rapid Evaluation of Liver Fat Content with In-Phase and Out-of-Phase MR Imaging ' , Radiology , vol. 250 , no. 1 , pp. 130-136 . https://doi.org/10.1148/radiol.2501071934 |
| سنة النشر: | 2009 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | MAGNETIC-RESONANCE-SPECTROSCOPY, HEPATIC TRIGLYCERIDE CONTENT, GENERAL-POPULATION, INSULIN-RESISTANCE, IRON OVERLOAD, GRADIENT-ECHO, RISK-FACTORS, QUANTIFICATION, STEATOSIS, STEATOHEPATITIS |
| الوصف: | Purpose: To evaluate in-phase and out-of-phase magnetic resonance (MR) imaging in the estimation of liver fat content (LFC) in patients with nonalcoholic fatty liver disease (NAFLD), with hydrogen (H-1) MR spectroscopy as the reference standard. Materials and Methods: Written informed consent was obtained from all subjects, and the local ethics committee approved this prospective study protocol. A total of 33 patients with type 2 diabetes mellitus who were at high risk for NAFLD (23 men, 10 women; overall mean age, 62.8 years +/- .3 [standard deviation]; age range, 48-77 years) underwent 1.5-T MR imaging with H-1 MR spectroscopy and in-phase and out-of-phase imaging of the liver. Three fat indexes were calculated from the signal intensity (SI) measured on the images. Two radiologists independently graded SI changes between in-phase and out-of-phase images by means of visual inspection. The Pearson correlation coefficient was used to study the relationship between the obtained parameters of SI change and LFC measured with H-1 MR spectroscopy. Results: Fat indexes calculated from in-phase and out-of-phase images correlated linearly with LFC measured with H-1 MR spectroscopy (P Conclusion: In-phase and out-of-phase imaging can be used to rapidly estimate the LFC in patients with NAFLD. The cutoff value of 5.1% enables objective rapid and reliable discrimination of normal LFC from elevated LFC. (C) RSNA, 2008 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://research.rug.nl/en/publications/2d8a387e-26c4-45d0-b96a-c2f3a61364c3 |
| DOI: | 10.1148/radiol.2501071934 |
| الاتاحة: | https://hdl.handle.net/11370/2d8a387e-26c4-45d0-b96a-c2f3a61364c3 https://research.rug.nl/en/publications/2d8a387e-26c4-45d0-b96a-c2f3a61364c3 https://doi.org/10.1148/radiol.2501071934 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.F4DDB487 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1148/radiol.2501071934 |
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