التفاصيل البيبلوغرافية
| العنوان: |
A dose response study of intravenous enoximone in congestive heart failure. |
| المؤلفون: |
ERBEL R, MEYER J, DIEFENBACH C, DELORME G, BOURDARIAS JP, VERNANT P, LELLOUCHE D, MATTIOLI G, INSTALL E, GONZALES M, MITROVIC V, NEUZNER J, SALVADE G., BARBIERI, Alberto |
| المساهمون: |
Erbel, R, Meyer, J, Diefenbach, C, Delorme, G, Bourdarias, Jp, Vernant, P, Lellouche, D, Mattioli, G, Barbieri, Alberto, Install, E, Gonzales, M, Mitrovic, V, Neuzner, J, Salvade, G. |
| بيانات النشر: |
EXCERPTA MEDICA INC, 650 AVENUE OF THE AMERICAS, NEW YORK, USA, NY, 10011 editore precedente: New York. Latest, New York Ny Excerpta Medica, Cahners Pub. Co. Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680 |
| سنة النشر: |
1987 |
| المجموعة: |
Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
| مصطلحات موضوعية: |
dose response, enoximone, congestive heart failure |
| الوصف: |
Previous clinical studies with intravenous enoximone have used cumulative dosing to quantify enoximone's hemodynamic effects. The magnitude and duration of the hemodynamic effects of single intravenous doses of enoximone were evaluated in patients with congestive heart failure. Sixty patients, who were in New York Heart Association functional classes III and IV, received single intravenous doses of enoximone, either 0.25 (12 patients), 0.5 (13 patients), 1 (14 patients), 1.5 (10 patients) or 2 mg/kg (11 patients). Cardiac index was increased by 20% with the 0.25 mg/kg dose and by 48% and 42% with the 1.5 and 2 mg/kg doses, respectively. These increases were statistically significant (Student's paired t test with Bonferroni's correction, p less than 0.007) for 1 hour after 0.25 and 0.5 mg/kg, for 2 hours after 1 mg/kg and for 4 hours after 1.5 and 2 mg/kg. Enoximone also reduced pulmonary artery diastolic pressure by 19% with 0.25 mg/kg and by 29% with 2 mg/kg. The duration of effect varied from 1 hour with 0.25 mg/kg to 4 hours with 2 mg/kg. Enoximone produced no consistent or dose-related effects on heart rate or blood pressure. Eighteen adverse reactions were reported by 15 patients, of which 11 were minor and transient (vein pain, flushes, nausea). In 5 patients ventricular or supraventricular arrhythmias were observed, including nonsustained ventricular tachycardia and extrasystoles; 3 of these patients had evidence of arrhythmias before enoximone. Laboratory studies before and after treatment showed no drug-related effects. Dose-related effects on the magnitude and duration of hemodynamic responses to intravenous enoximone were evident within the dose range of 0.25 to 2 mg/kg.(ABSTRACT TRUNCATED AT 250 WORDS) |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
STAMPA |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/2956865; info:eu-repo/semantics/altIdentifier/wos/WOS:A1987J679600007; volume:60; firstpage:31c; lastpage:36c; journal:THE AMERICAN JOURNAL OF CARDIOLOGY; http://hdl.handle.net/11380/448588 |
| الاتاحة: |
http://hdl.handle.net/11380/448588 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| رقم الانضمام: |
edsbas.F4D52015 |
| قاعدة البيانات: |
BASE |