Academic Journal
Infection with Toxoplasma gondii Reduces Established and Developing Th2 Responses Induced by Nippostrongylus brasiliensis Infection
| العنوان: | Infection with Toxoplasma gondii Reduces Established and Developing Th2 Responses Induced by Nippostrongylus brasiliensis Infection |
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| المؤلفون: | Liesenfeld, Oliver, Dunay, Ildiko R., Erb, Klaus J. |
| المصدر: | Infection and Immunity ; volume 72, issue 7, page 3812-3822 ; ISSN 0019-9567 1098-5522 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2004 |
| الوصف: | Oral infection of C57BL/6 mice with 100 cysts of the protozoan parasite Toxoplasma gondii results in the development of small intestinal Th1-type immunopathology. In contrast, infection with intestinal helminths results in the development of protective Th2-type responses. We investigated whether infection with the helminth Nippostrongylus brasiliensis influences the development of T. gondii -induced Th1 responses and immunopathology in C57BL/6 mice infected with T. gondii . Prior as well as simultaneous infection of mice with N. brasiliensis did not alter the course of infection with 100 cysts of T. gondii . Coinfected mice produced high levels of interleukin-12 (IL-12) and gamma interferon (IFN-γ), developed small intestinal immunopathology, and died at the same time as mice infected with T. gondii . Interestingly, local and systemic N. brasiliensis -induced Th2 responses, including IL-4 and IL-5 production by mesenteric lymph node and spleen cells and numbers of intestinal goblet cells and blood eosinophils, were markedly lower in coinfected than in N. brasiliensis -infected mice. Similar effects were seen when infection with 10 T. gondii cysts was administered following infection with N. brasiliensis . Infection of C57BL/6 mice with 10 T. gondii cysts prior to coinfection with N. brasiliensis inhibited the development of helminth-induced Th2 responses and was associated with higher and prolonged N. brasiliensis egg production. In contrast, oral administration of Toxoplasma lysate prior to N. brasiliensis infection had only a minor and short-lived effect on Th2 responses. Thus, N. brasiliensis -induced Th2 responses fail to alter T. gondii -induced Th1 responses and immunopathology, most likely because Th1 responses develop unchanged in C57BL/6 mice with a prior or simultaneous infection with N. brasiliensis . Our findings contribute to the understanding of immune regulation in coinfected animals and may assist in the design of immunotherapies for human Th1 and Th2 disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/iai.72.7.3812-3822.2004 |
| DOI: | 10.1128/IAI.72.7.3812-3822.2004 |
| الاتاحة: | http://dx.doi.org/10.1128/iai.72.7.3812-3822.2004 https://journals.asm.org/doi/pdf/10.1128/IAI.72.7.3812-3822.2004 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.F4BE0C2E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/iai.72.7.3812-3822.2004 |
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