Academic Journal
Protective effects of S-allyl cysteine on behavioral, morphological and biochemical alterations in rats subjected to chronic restraint stress: Antioxidant and anxiolytic effects
| العنوان: | Protective effects of S-allyl cysteine on behavioral, morphological and biochemical alterations in rats subjected to chronic restraint stress: Antioxidant and anxiolytic effects |
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| المؤلفون: | Hugo Becerril-Chávez, Ana Laura Colín-González, Juana Villeda-Hernández, Sonia Galván-Arzate, Anahí Chavarría, María Eduarda de Lima, Isaac Túnez, Abel Santamaría |
| المصدر: | Journal of Functional Foods, Vol 35, Iss , Pp 105-114 (2017) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Restraint stress, Brain regions, Oxidative stress, Cell protection, S-allyl cysteine, Antioxidant defense, Nutrition. Foods and food supply, TX341-641 |
| الوصف: | S-allyl cysteine (SAC) is a garlic-derived compound with antioxidant properties. Restraint stress constitutes a rodent model mimicking different features of human stress. The effects of SAC on behavioral, biochemical and morphological endpoints of brain alterations induced by chronic restraint stress were evaluated in rats. Restraint stress sessions were performed every day for 6 h during 21 consecutive days. SAC (100 mg/kg, i.p.) was administered daily 30 min before every single stress session. Behavioral tests comprised anxiety-like and depression-like challenges. Biochemical and morphological endpoints were estimated in three brain regions: striatum, hippocampus and cortex. Stressed animals exhibited augmented anxiety-like behavior, depression and morphological alterations, and these changes were accompanied by increased oxidative damage, compensatory regulation of antioxidant enzymes, and increased corticosterone plasma levels. SAC prevented anxiety-like behavior elicited by chronic stress in rats, and reduced morphological and biochemical alterations. The protective actions of SAC are related to its antioxidant properties. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1756-4646 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1756464617302785; https://doaj.org/toc/1756-4646; https://doaj.org/article/03436924cd0a433aaeded54f5cdac6c8 |
| DOI: | 10.1016/j.jff.2017.05.034 |
| الاتاحة: | https://doi.org/10.1016/j.jff.2017.05.034 https://doaj.org/article/03436924cd0a433aaeded54f5cdac6c8 |
| رقم الانضمام: | edsbas.F4A47A54 |
| قاعدة البيانات: | BASE |
| تدمد: | 17564646 |
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| DOI: | 10.1016/j.jff.2017.05.034 |