Academic Journal
Multi-center study on the characteristics and treatment strategies of patients with Graves' orbitopathy: the first European Group on Graves' Orbitopathy experience
| العنوان: | Multi-center study on the characteristics and treatment strategies of patients with Graves' orbitopathy: the first European Group on Graves' Orbitopathy experience |
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| المؤلفون: | Prummel, MF, Bakker, A, Wiersinga, WM, Baldeschi, L, Mourits, MP, Kendall-Taylor, P, Perros, P, Neoh, C, Dickinson, AJ, Lazarus, JH, Lane, CM, Heufelder, AE, Kahaly, GJ, Pitz, S, Orgiazzi, J, Hullo, A, Pinchera, A, Marcocci, C, Sartini, MS, Rocchi, R, Nardi, M, Krassas, GE, Halkias, A |
| المصدر: | European Journal of Endocrinology ; volume 148, issue 5, page 491-495 ; ISSN 0804-4643 1479-683X |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2003 |
| الوصف: | To improve management of patients with Graves' orbitopathy, a multi-center collaborative approach is necessary in order to have large enough sample sizes for meaningful randomized clinical trials. This is hampered by a lack of consensus on how to investigate the eye condition. The European Group on Graves' Orbitopathy aims to overcome this and has designed a preliminary case record form (CRF) to assess Graves' orbitopathy patients. This form was used in this first multi-center study. AIM: To investigate patient characteristics and treatment strategies in 152 new consecutively referred patients with thyroid eye disease seen in nine large European referral centers. METHODS: Newly referred patients with Graves' orbitopathy were included who were seen between September and December 2000. Demographic data and a complete ophthalmological assessment were recorded. RESULTS: One-hundred and fifty-two patients (77% females) were included. Diabetes was present in 9%, and glaucoma or cataract in 14% of patients. Forty percent were current smokers, 9% also had dermopathy, and only 33% reported a positive family history of thyroid disease. Mild eye disease was seen in 40%, moderately severe eye disease was seen in 33% and severe eye disease was seen in 28% of patients. Soft tissue involvement was the most frequent abnormality (seen in 75%), proptosis > or =21 mm was found in 63%, eye motility dysfunction in 49%, keratopathy in 16% and optic nerve involvement was found in 21% of patients. According to the clinical impression, 60% had active eye disease. Immunosuppressive treatment was planned more frequently in active patients (57/86; 66%) than in inactive patients (5/57, 9%; Chi-square 46.16; P<0.02). There were no important differences among the eight centers regarding the severity and the activity of their patients. CONCLUSIONS: In view of the large number of patients recruited in only 4 months, multi-center studies in the eight EUGOGO centers appear to be feasible. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.1530/eje.0.1480491 |
| الاتاحة: | http://dx.doi.org/10.1530/eje.0.1480491 https://eje.bioscientifica.com/view/journals/eje/148/5/491.xml |
| رقم الانضمام: | edsbas.F4877B6F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1530/eje.0.1480491 |
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