Academic Journal
Fate mapping analysis reveals a novel murine dermal migratory Langerhans-like cell population
| العنوان: | Fate mapping analysis reveals a novel murine dermal migratory Langerhans-like cell population |
|---|---|
| المؤلفون: | Sheng, Jianpeng, Chen, Qi, Wu, Xiaoting, Dong, Yu Wen, Mayer, Johannes, Zhang, Junlei, Wang, Lin, Bai, Xueli, Liang, Tingbo, Sung, Yang Ho, Goh, Wilson Wen Bin, Ronchese, Franca, Ruedl, Christiane |
| المساهمون: | School of Biological Sciences |
| سنة النشر: | 2021 |
| المجموعة: | DR-NTU (Digital Repository at Nanyang Technological University, Singapore) |
| مصطلحات موضوعية: | Science::Medicine, Dermal Dendritic Cells, Langerhans Cells |
| الوصف: | Dendritic cells residing in the skin represent a large family of antigen-presenting cells, ranging from long-lived Langerhans cells (LC) in the epidermis to various distinct classical dendritic cell subsets in the dermis. Through genetic fate mapping analysis and single-cell RNA-sequencing, we have identified a novel separate population of LC-independent CD207⁺CD326⁺ LClike cells in the dermis that homed at a slow rate to the lymph nodes (LNs). These LClike cells are long-lived and radio-resistant but, unlike LCs, they are gradually replenished by bone marrow-derived precursors under steady state. LClike cells together with cDC1s are the main migratory CD207⁺CD326⁺ cell fractions present in the LN and not, as currently assumed, LCs, which are barely detectable, if at all. Cutaneous tolerance to haptens depends on LClike cells, whereas LCs suppress effector CD8⁺ T-cell functions and inflammation locally in the skin during contact hypersensitivity. These findings bring new insights into the dynamism of cutaneous dendritic cells and their function opening novel avenues in the development of treatments to cure inflammatory skin disorders. ; Ministry of Education (MOE) ; Published version ; The authors would like to thank Monika Tetlak for mouse management, Su I-hsin and Lim Jun Feng Thomas, for technical advice and Insight Editing London for proofreading the manuscript prior to submission. This work was supported by Ministry of Education Tier1 grant awarded to CR and by the National Key R and D Program of China (Grant 2019YFA0803000) assigned to JS. Work at the MIMR was supported by an Independent Research Organisation Work at the MIMR was supported by a Health Research Council of New Zealand Independent Research Organisation grant to the Malaghan Institute of Medical Research awarded to the Malaghan Institute of Medical Research from the Health Research Council of New Zealand. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | eLife; Sheng, J., Chen, Q., Wu, X., Dong, Y. W., Mayer, J., Zhang, J., Wang, L., Bai, X., Liang, T., Sung, Y. H., Goh, W. W. B., Ronchese, F. & Ruedl, C. (2021). Fate mapping analysis reveals a novel murine dermal migratory Langerhans-like cell population. ELife, 10, e65412-. https://dx.doi.org/10.7554/eLife.65412; https://hdl.handle.net/10356/151764; 2-s2.0-85103330506; 10; e65412 |
| DOI: | 10.7554/eLife.65412 |
| الاتاحة: | https://hdl.handle.net/10356/151764 https://doi.org/10.7554/eLife.65412 |
| Rights: | © 2021, Sheng et al.This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
| رقم الانضمام: | edsbas.F47A7F8A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2050084X |
|---|---|
| DOI: | 10.7554/eLife.65412 |