التفاصيل البيبلوغرافية
| العنوان: |
Data underlying Fig 4B and 4C. |
| المؤلفون: |
Marta Galanti, Juan Angel Patiño-Galindo, Ioan Filip, Haruka Morita, Angelica Galianese, Mariam Youssef, Devon Comito, Chanel Ligon, Benjamin Lane, Nelsa Matienzo, Sadiat Ibrahim, Eudosie Tagne, Atinuke Shittu, Oliver Elliott, Tomin Perea-Chamblee, Sanjay Natesan, Daniel Scholes Rosenbloom, Jeffrey Shaman, Raul Rabadan |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Microbiology, Genetics, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, specific results include, significant transcriptomic differences, several factors beyond, new york city, host transcriptomic changes, host genetic makeup, interactive computational resource, cause serious disease, virome data explorer, transcriptomic data enabled, web resource, disease severity, clinical data, symptom severity, signatures associated, rapid restoration, nasopharyngeal samples, infectious agent, individual viruses, immune response, facilitate access |
| الوصف: |
Viral respiratory infections are an important public health concern due to their prevalence, transmissibility, and potential to cause serious disease. Disease severity is the product of several factors beyond the presence of the infectious agent, including specific host immune responses, host genetic makeup, and bacterial coinfections. To understand these interactions within natural infections, we designed a longitudinal cohort study actively surveilling respiratory viruses over the course of 19 months (2016 to 2018) in a diverse cohort in New York City. We integrated the molecular characterization of 800+ nasopharyngeal samples with clinical data from 104 participants. Transcriptomic data enabled the identification of respiratory pathogens in nasopharyngeal samples, the characterization of markers of immune response, the identification of signatures associated with symptom severity, individual viruses, and bacterial coinfections. Specific results include a rapid restoration of baseline conditions after infection, significant transcriptomic differences between symptomatic and asymptomatic infections, and qualitatively similar responses across different viruses. We created an interactive computational resource (Virome Data Explorer) to facilitate access to the data and visualization of analytical results. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/Data_underlying_Fig_4B_and_4C_/25023893 |
| DOI: |
10.1371/journal.pbio.3002089.s019 |
| الاتاحة: |
https://doi.org/10.1371/journal.pbio.3002089.s019
https://figshare.com/articles/dataset/Data_underlying_Fig_4B_and_4C_/25023893 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.F450C985 |
| قاعدة البيانات: |
BASE |