Academic Journal
Clinical and MRI measures to identify non-acute MOG-antibody disease in adults
| العنوان: | Clinical and MRI measures to identify non-acute MOG-antibody disease in adults |
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| المؤلفون: | Cortese, Rosa, Battaglini, Marco, Prados, Ferran, Bianchi, Alessia, Haider, Lukas, Jacob, Anu, Palace, Jacqueline, Messina, Silvia, Paul, Friedemann, Wuerfel, Jens, Marignier, Romain, Durand-Dubief, Françoise, de Medeiros Rimkus, Carolina, Callegaro, Dagoberto, Sato, Douglas Kazutoshi, Filippi, Massimo, Rocca, Maria Assunta, Cacciaguerra, Laura, Rovira, Alex, Sastre-Garriga, Jaume, Arrambide, Georgina, Liu, Yaou, Duan, Yunyun, Gasperini, Claudio, Tortorella, Carla, Ruggieri, Serena, Amato, Maria Pia, Ulivelli, Monica, Groppa, Sergiu, Grothe, Matthias, Llufriu, Sara, Sepulveda, Maria, Lukas, Carsten, Bellenberg, Barbara, Schneider, Ruth, Sowa, Piotr, Celius, Elisabeth G, Proebstel, Anne-Katrin, Yaldizli, Özgür, Müller, Jannis, Stankoff, Bruno, Bodini, Benedetta, Carmisciano, Luca, Sormani, Maria Pia, Barkhof, Frederik, De Stefano, Nicola, Ciccarelli, Olga |
| المساهمون: | Cortese, Rosa, Battaglini, Marco, Prados, Ferran, Bianchi, Alessia, Haider, Luka, Jacob, Anu, Palace, Jacqueline, Messina, Silvia, Paul, Friedemann, Wuerfel, Jen, Marignier, Romain, Durand-Dubief, Françoise, de Medeiros Rimkus, Carolina, Callegaro, Dagoberto, Sato, Douglas Kazutoshi, Filippi, Massimo, Rocca, Maria Assunta, Cacciaguerra, Laura, Rovira, Alex, Sastre-Garriga, Jaume, Arrambide, Georgina, Liu, Yaou, Duan, Yunyun, Gasperini, Claudio, Tortorella, Carla, Ruggieri, Serena, Amato, Maria Pia, Ulivelli, Monica, Groppa, Sergiu, Grothe, Matthia, Llufriu, Sara, Sepulveda, Maria, Lukas, Carsten, Bellenberg, Barbara, Schneider, Ruth, Sowa, Piotr, Celius, Elisabeth G, Proebstel, Anne-Katrin, Yaldizli, Özgür, Müller, Janni, Stankoff, Bruno, Bodini, Benedetta, Carmisciano, Luca, Sormani, Maria Pia, Barkhof, Frederik, De Stefano, Nicola, Ciccarelli, Olga |
| سنة النشر: | 2023 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | aquaporin 4-antibody positive neuromyelitis optica spectrum disorder, differential diagnosis, imaging, multiple sclerosis, myelin oligodendrocyte glycoprotein antibody-associated disease |
| الوصف: | MRI and clinical features of myelin oligodendrocyte glycoprotein (MOG)-antibody disease may overlap with those of other inflammatory demyelinating conditions posing diagnostic challenges, especially in non-acute phases and when serologic testing for MOG-antibodies is unavailable or shows uncertain results. We aimed to identify MRI and clinical markers that differentiate non-acute MOG-antibody disease from aquaporin4 (AQP4)-antibody neuromyelitis optica spectrum disorder and relapsing remitting multiple sclerosis, guiding in the identification of MOG-antibody disease patients in clinical practice. In this cross-sectional retrospective study, data from 16 MAGNIMS centres were included. Data collection and analyses were conducted from 2019 to 2021. Inclusion criteria were: diagnosis of MOG-antibody disease, AQP4-neuromyelitis optica spectrum disorder and multiple sclerosis, brain and cord MRI at least 6 months from relapse, EDSS on the day of MRI. Brain white matter T2 lesions, T1-hypointense lesions, cortical and cord lesions were identified. Random-forest models were constructed to classify patients as MOG-antibody disease/AQP4-neuromyelitis optica spectrum disorder/multiple sclerosis; a leave one out cross-validation procedure assessed the performance of the models. Based on the best discriminators between diseases, we proposed a guide to target investigations for MOG-antibody disease. One hundred sixty-two patients with MOG-antibody disease (99F, mean age: 41 [±14] years, median EDSS: 2 [0-7.5]), 162 with AQP4-neuromyelitis optica spectrum disorder (132F, mean age: 51 [±14] years, median EDSS: 3.5 [0-8]), 189 with multiple sclerosis (132F, mean age: 40 [±10] years, median EDSS: 2 [0-8]) and 152 healthy controls (91F) were studied. In young patients (<34 years), with low disability (EDSS < 3), the absence of Dawson's fingers, temporal lobe lesions and longitudinally extensive lesions in the cervical cord pointed towards a diagnosis of MOG-antibody disease instead of the other two diseases (accuracy: 76%, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36515653; volume:146; issue:6; firstpage:2489; lastpage:2501; numberofpages:13; journal:BRAIN; https://hdl.handle.net/10447/580093 |
| DOI: | 10.1093/brain/awac480 |
| الاتاحة: | https://hdl.handle.net/10447/580093 https://doi.org/10.1093/brain/awac480 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F42EFA4B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/brain/awac480 |
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