Academic Journal
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy
| العنوان: | LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy |
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| المؤلفون: | Pascual García, Mónica, Bonfill Teixidor, Ester, Planas Rigol, Ester, Rubio-Perez, Carlota, Iurlaro, Raffaella, Arias Piñeiro, Alexandra, Cuartas Maza, Ma Isabel, Sala Hojman, Ada, Escudero Monreal, Laura, Martínez Ricarte, Francisco Ramón, Huber Ruano, Isabel, Nuciforo, Paolo Giovanni, Braña Garcia, Irene, Garralda Cabanas, Elena, Vieito Villar, Maria, Espejo Ruiz, Carmen, Sahuquillo Barris, Joan, Tabernero Caturla, Josep, Seoane Suarez, Joan |
| المساهمون: | Institut Català de la Salut, Pascual-García M, Bonfill-Teixidor E Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. CIBERONC, Madrid, Spain. Planas-Rigol E, Rubio-Perez C, Iurlaro R, Arias A, Cuartas I, Sala-Hojman A, Escudero L, Huber-Ruano I, Nuciforo P, Braña I, Garralda E, Vieito M Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Martínez-Ricarte F, Espejo C, Sahuquillo J Vall d’Hebron Institut de Recerca, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. Tabernero J Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. CIBERONC, Madrid, Spain. Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. Seoane J Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. CIBERONC, Madrid, Spain. Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Medicaments antineoplàstics, Cèl·lules T - Immunologia, Citocines - Immunologia, Tumors - Tractament, DISEASES::Neoplasms, Other subheadings::Other subheadings::Other subheadings::/drug therapy, CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Leukemia Inhibitory Factor, ANATOMY::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes::CD8-Positive T-Lymphocytes, Other subheadings::Other subheadings::Other subheadings::/immunology, ENFERMEDADES::neoplasias, Otros calificadores::Otros calificadores::Otros calificadores::/tratamiento farmacológico, COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intercelular::citocinas::factor inhibidor de la leucemia, ANATOMÍA::células::células sanguíneas::leucocitos::leucocitos mononucleares::linfocitos::linfocitos T::linfocitos T CD8-positivos, Otros calificadores::Otros calificadores::Otros calificadores::/inmunología |
| الوصف: | Càncer; Macròfags associats al tumor: LIF; CD8 ; Cáncer; Macrófagos asociados al tumor; CD8 ; Cancer; Tumor-associated macrophages; CD8 ; Cancer response to immunotherapy depends on the infiltration of CD8+ T cells and the presence of tumor-associated macrophages within tumors. Still, little is known about the determinants of these factors. We show that LIF assumes a crucial role in the regulation of CD8+ T cell tumor infiltration, while promoting the presence of protumoral tumor-associated macrophages. We observe that the blockade of LIF in tumors expressing high levels of LIF decreases CD206, CD163 and CCL2 and induces CXCL9 expression in tumor-associated macrophages. The blockade of LIF releases the epigenetic silencing of CXCL9 triggering CD8+ T cell tumor infiltration. The combination of LIF neutralizing antibodies with the inhibition of the PD1 immune checkpoint promotes tumor regression, immunological memory and an increase in overall survival. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| Relation: | Nature Communications;10(1); https://www.nature.com/articles/s41467-019-10369-9; Pascual-García M, Bonfill-Teixidor E, Planas-Rigol E, Rubio-Perez C, Iurlaro R, Arias A, et al. LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy. Nat Commun. 2019;10(1):2416.; https://hdl.handle.net/11351/4218 |
| DOI: | 10.1038/s41467-019-10369-9 |
| الاتاحة: | https://hdl.handle.net/11351/4218 https://doi.org/10.1038/s41467-019-10369-9 |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F42A4126 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-019-10369-9 |