Academic Journal
Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction
| العنوان: | Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction |
|---|---|
| المؤلفون: | Espino-Gonzalez, E., Tickle, P.G., Altara, R., Gallagher, H., Cheng, C.W., Engman, V., Wood, N., Justo da Silva, G.J., Scalabrin, M., Yu, X., Zhong, Z., Colman, M.A., Yuldasheva, N.Y., Booz, G.W., Adams, V., Pereira, M.G., Cataliotti, A., Roberts, L.D., Egginton, S., Bowen, T.S. |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2024 |
| المجموعة: | White Rose Research Online (Universities of Leeds, Sheffield & York) |
| الوصف: | Heart failure with preserved ejection fraction (HFpEF) is a major clinical problem, with limited treatments. HFpEF is characterized by a distinct, but poorly understood, skeletal muscle pathology, which could offer an alternative therapeutic target. In a rat model, we identified impaired myonuclear accretion as a mechanism for low myofiber growth in HFpEF following resistance exercise. Acute caloric restriction rescued skeletal muscle pathology in HFpEF, whereas cardiac therapies had no effect. Mechanisms regulating myonuclear accretion were dysregulated in patients with HFpEF. Overall, these findings may have widespread implications in HFpEF, indicating combined dietary with exercise interventions as a beneficial approach to overcome skeletal muscle pathology. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://eprints.whiterose.ac.uk/206601/1/1-s2.0-S2452302X2300462X-main.pdf; Espino-Gonzalez, E., Tickle, P.G., Altara, R. et al. (17 more authors) (2024) Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction. JACC: Basic to Translational Science, 9 (2). pp. 223-240. ISSN 2452-302X |
| الاتاحة: | https://eprints.whiterose.ac.uk/206601/ https://eprints.whiterose.ac.uk/206601/1/1-s2.0-S2452302X2300462X-main.pdf |
| Rights: | cc_by_4 |
| رقم الانضمام: | edsbas.F417F3BA |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |