Academic Journal
Anisomycin prevents OGD-induced necroptosis by regulating the E3 ligase CHIP
| العنوان: | Anisomycin prevents OGD-induced necroptosis by regulating the E3 ligase CHIP |
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| المؤلفون: | Tang, M.-B., Li, Y.-S., Li, S.-H., Cheng, Y., Zhang, S., Luo, H.-Y., Mao, C.-Y., Hu, Z.-W., Schisler, J.C., Shi, C.-H., Xu, Y.-M. |
| المصدر: | Scientific Reports, 8(1) |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2018 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Gene Expression Regulation, Enzymologic, Rats, Mice, Oxygen, Neuroblastoma, Female, Anisomycin, Ubiquitin-Protein Ligases, Animals, Ubiquitin, Glucose, Necrosis, Apoptosis, Cell Hypoxia, Anti-Bacterial Agents, Sprague-Dawley |
| الوصف: | Necroptosis is an essential pathophysiological process in cerebral ischemia-related diseases. Therefore, targeting necroptosis may prevent cell death and provide a much-needed therapy. Ansiomycin is an inhibitor of protein synthesis which can also activate c-Jun N-terminal kinases. The present study demonstrated that anisomycin attenuated necroptosis by upregulating CHIP (carboxyl terminus of Hsc70-interacting protein) leading to the reduced levels of receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3) proteins in two in vitro models of cerebral ischemia. Further exploration in this research revealed that losing neither the co-chaperone nor the ubiquitin E3 ligase function of CHIP could abolish its ability to reduce necroptosis. Collectively, this study identifies a novel means of preventing necroptosis in two in vitro models of cerebral ischemia injury through activating the expression of CHIP, and it may provide a potential target for the further study of the disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.17615/6wh3-bz77; https://cdr.lib.unc.edu/downloads/05741z40j?file=thumbnail; https://cdr.lib.unc.edu/downloads/05741z40j |
| DOI: | 10.17615/6wh3-bz77 |
| الاتاحة: | https://doi.org/10.17615/6wh3-bz77 https://cdr.lib.unc.edu/downloads/05741z40j?file=thumbnail https://cdr.lib.unc.edu/downloads/05741z40j |
| Rights: | http://rightsstatements.org/vocab/InC/1.0/ |
| رقم الانضمام: | edsbas.F3E07AC |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/6wh3-bz77 |
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