Academic Journal
Effectiveness of influenza vaccination and early antiviral treatment in reducing pneumonia risk in severe influenza cases
| العنوان: | Effectiveness of influenza vaccination and early antiviral treatment in reducing pneumonia risk in severe influenza cases |
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| المؤلفون: | Godoy Garcia, Pere, Soldevila, Nuria, Martínez Mateo, Ana, Godoy García, Sofia, Jané Checa, Mireia, Torner, Núria, Acosta Argueta, Lesly María, Rius Gibert, Cristina, Domínguez García, Ángela |
| المساهمون: | Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. ADBD - Anàlisi de Dades Complexes per a les Decisions Empresarials |
| سنة النشر: | 2024 |
| المجموعة: | Universitat Politècnica de Catalunya, BarcelonaTech: UPCommons - Global access to UPC knowledge |
| مصطلحات موضوعية: | Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística aplicada, Pneumonia, Vaccination, Influenza, Antiviral treatment, Pneumònia, Vacunació |
| الوصف: | Introduction: Influenza vaccination may be effective in preventing influenza infection and may reduce the risk of influenza-associated pneumonia. The study aim was to evaluate the effect of influenza vaccination in preventing pneumonia when it failed to prevent influenza hospitalization. Methods: This was a case–control study comparing hospitalized cases of influenza with and without pneumonia in patients aged =18 years in 16 hospitals in Catalonia over 10 influenza seasons (2010–11 to 2019–20). Data on sociodemographic, virological characteristics, comorbidities, vaccination history, and antiviral treatment were collected and analysed. The crude odds ratio (OR) and adjusted OR (aOR) with the corresponding 95% confidence interval (CI) values were calculated. Results: In total, 5080 patients hospitalized for severe influenza were included, 63.5% (3224/5080) of whom had pneumonia—mostly men (56.8%; 1830/3224) and mostly in the =75 age group (39.3%; 1267/3224)—and of whom 14.0% died (451/3224). Virus A and virus B accounted for 78.1% (2518/3224) and 21.9% (705/3224) of influenza types, respectively. Starting antiviral treatment =48 h after symptom onset (aOR = 0.69; 95%CI: 0.53–0.90) and a history of seasonal influenza vaccination (aOR = 0.85; 95%CI: 0.72–0.98) were protective factors in developing pneumonia. Conclusions: Adherence to seasonal influenza vaccination and starting antiviral treatment within 48 h of symptom onset can reduce pneumonia risk in severe influenza cases. ; This study was supported by the Programme of Prevention, Surveillance and Control of Transmissible Diseases (PREVICET), CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid and the Catalan Agency for the Management of Grants for University Research (AGAUR Grant Number 2017/SGR 1342 and Grant Number 2021/SGR 00702). The funders had no role in the study design, data collection and analysis, the decision to publish or preparation of the manuscript. ; Peer Reviewed ; Postprint (published version) |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-393X |
| Relation: | https://www.mdpi.com/2076-393X/12/2/173; Godoy, P. [et al.]. Effectiveness of influenza vaccination and early antiviral treatment in reducing pneumonia risk in severe influenza cases. "Vaccines", 7 Febrer 2024, vol. 12, núm. 2, article 173.; http://hdl.handle.net/2117/404433 |
| DOI: | 10.3390/vaccines12020173 |
| الاتاحة: | http://hdl.handle.net/2117/404433 https://doi.org/10.3390/vaccines12020173 |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; Open Access |
| رقم الانضمام: | edsbas.F39CFC04 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2076393X |
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| DOI: | 10.3390/vaccines12020173 |