Academic Journal
Comparison of anatomical-based vs. nTMS-based risk stratification model for predicting postoperative motor outcome and extent of resection in brain tumor surgery
| العنوان: | Comparison of anatomical-based vs. nTMS-based risk stratification model for predicting postoperative motor outcome and extent of resection in brain tumor surgery |
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| المؤلفون: | Ivren, Meltem, Grittner, Ulrike, Khakhar, Rutvik, Belotti, Francesco, Schneider, Heike, Pöser, Paul, D’Agata, Federico, Spena, Giannantonio, Vajkoczy, Peter, Picht, Thomas, Rosenstock, Tizian |
| بيانات النشر: | Humboldt-Universität zu Berlin |
| سنة النشر: | 2023 |
| المجموعة: | Open-Access-Publikationsserver der Humboldt-Universität: edoc-Server |
| مصطلحات موضوعية: | Motor outcome, Brain tumor surgery, Navigated transcranial magnetic stimulation (nTMS), diffusion tensor imaging (DTI), Glioma, Extent of resection, 610 Medizin und Gesundheit, ddc:610 |
| الوصف: | The authors acknowledge the support of the Cluster of Excellence Matters of Activity. Image Space Material funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germanýs Excellence Strategy – EXC 2025. Dr. Rosenstock is participant in the BIH Charité Digital Clinician Scientist Program funded by the Charité – Universitätsmedizin Berlin, and the Berlin Institute of Health at Charité (BIH). Dr. Belotti received fundings from the Italian Society of Neurosurgery - “Premio Melitta Grasso Tomasello” and the Beretta Foundation for Cancer Study - “European Scholarship on Oncology”. ; Background: Two statistical models have been established to evaluate characteristics associated with postoperative motor outcome in patients with glioma associated to the motor cortex (M1) or the corticospinal tract (CST). One model is based on a clinicoradiological prognostic sum score (PrS) while the other one relies on navigated transcranial magnetic stimulation (nTMS) and diffusion-tensor-imaging (DTI) tractography. The objective was to compare the models regarding their prognostic value for postoperative motor outcome and extent of resection (EOR) with the aim of developing a combined, improved model. Methods: We retrospectively analyzed a consecutive prospective cohort of patients who underwent resection for motor associated glioma between 2008 and 2020, and received a preoperative nTMS motor mapping with nTMS-based diffusion tensor imaging tractography. The primary outcomes were the EOR and the motor outcome (on the day of discharge and 3 months postoperatively according to the British Medical Research Council (BMRC) grading). For the nTMS model, the infiltration of M1, tumor-tract distance (TTD), resting motor threshold (RMT) and fractional anisotropy (FA) were assesed. For the PrS score (ranging from 1 to 8, lower scores indicating a higher risk), we assessed tumor margins, volume, presence of cysts, contrast agent enhancement, MRI index (grading white matter infiltration), preoperative seizures or ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2213-1582 |
| Relation: | http://edoc.hu-berlin.de/18452/29244; urn:nbn:de:kobv:11-110-18452/29244-2; http://dx.doi.org/10.18452/28619; https://doi.org/10.1016/j.nicl.2023.103436 |
| DOI: | 10.18452/28619 |
| DOI: | 10.1016/j.nicl.2023.103436 |
| الاتاحة: | http://edoc.hu-berlin.de/18452/29244 https://nbn-resolving.org/urn:nbn:de:kobv:11-110-18452/29244-2 https://doi.org/10.18452/28619 https://doi.org/10.1016/j.nicl.2023.103436 |
| Rights: | (CC BY 4.0) Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.F38F90EB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22131582 |
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| DOI: | 10.18452/28619 |