التفاصيل البيبلوغرافية
| العنوان: |
Hormetic Response to Low-Dose Radiation: Focus on the Immune System and Its Clinical Implications |
| المؤلفون: |
Jiuwei Cui, Guozi Yang, Zhenyu Pan, Yuguang Zhao, Xinyue Liang, Wei Li, Lu Cai |
| المصدر: |
International Journal of Molecular Sciences; Volume 18; Issue 2; Pages: 280 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2017 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
low-dose radiation, hormesis, immune stimulating, immune therapy, autoimmune disease, cancer therapy |
| جغرافية الموضوع: |
agris |
| الوصف: |
The interrelationship between ionizing radiation and the immune system is complex, multifactorial, and dependent on radiation dose/quality and immune cell type. High-dose radiation usually results in immune suppression. On the contrary, low-dose radiation (LDR) modulates a variety of immune responses that have exhibited the properties of immune hormesis. Although the underlying molecular mechanism is not fully understood yet, LDR has been used clinically for the treatment of autoimmune diseases and malignant tumors. These advancements in preclinical and clinical studies suggest that LDR-mediated immune modulation is a well-orchestrated phenomenon with clinical potential. We summarize recent developments in the understanding of LDR-mediated immune modulation, with an emphasis on its potential clinical applications. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Molecular Toxicology; https://dx.doi.org/10.3390/ijms18020280 |
| DOI: |
10.3390/ijms18020280 |
| الاتاحة: |
https://doi.org/10.3390/ijms18020280 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.F37209A2 |
| قاعدة البيانات: |
BASE |