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Protein sequestration is a key antioxidant defence mechanism that functions to mitigate the damaging consequences of protein oxidation.
| العنوان: | Protein sequestration is a key antioxidant defence mechanism that functions to mitigate the damaging consequences of protein oxidation. |
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| المؤلفون: | Zorana Carter, Declan Creamer, Aikaterini Kouvidi, Chris M. Grant |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Evolutionary Biology, Cancer, Inorganic Chemistry, Infectious Diseases, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, quality control mechanisms, play key roles, div >< p, >< sup ><, sequester oxidized proteins, prion formation occurs, multiple intracellular sites, heritable prion form, insoluble protein deposit, sequestrase chaperones protect, oxidative stress conditions, exact intracellular functions, induced protein aggregation, amyloid sup35 aggregates, btn2 hsp42 <, oxidative stress, induced formation, amyloid form |
| الوصف: | Soluble proteins such as Sup35 that undergo misfolding in response to oxidative damage are normally triaged by Btn2 and Hsp42 to the various protein deposit sites in cells. In the absence of Hsp42 and Btn2, protein sequestration is deficient and non-specific protein aggregates accumulate in cells. These aggregates are targeted by Hsp104 and other chaperones, but non-specific aggregates ultimately overwhelm the protein homeostasis machinery resulting in sensitivity to oxidative stress conditions. De novo prion formation following protein oxidation depends on IPOD localization which acts as a sorting centre determining whether oxidized proteins are cleared via autophagy, or alternatively, form heritable protein aggregates (prions), dependent on Hsp104. Prion formation is increased in btn2 hsp42 mutants in response to ROS exposure independent of IPOD localization. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/figure/Protein_sequestration_is_a_key_antioxidant_defence_mechanism_that_functions_to_mitigate_the_damaging_consequences_of_protein_oxidation_/25320273 |
| DOI: | 10.1371/journal.pgen.1011194.g007 |
| الاتاحة: | https://doi.org/10.1371/journal.pgen.1011194.g007 https://figshare.com/articles/figure/Protein_sequestration_is_a_key_antioxidant_defence_mechanism_that_functions_to_mitigate_the_damaging_consequences_of_protein_oxidation_/25320273 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.F365BC9D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pgen.1011194.g007 |
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