Academic Journal
Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people
| العنوان: | Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people |
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| المؤلفون: | Herrero-Fernández, I., Rosado-Sánchez, I., Álvarez-Ríos, A. I., Galvá, M. I., De Luna-Romero, M., Sanbonmatsu-Gámez, S., Pérez-Ruiz, M., Navarro-Marí, J. M., Carrillo-Vico, A., Sánchez, B., Ramos, R., Cañizares, J., Leal, M., Pacheco, Y. M. |
| المساهمون: | Herrero-Fernandez,I, Rosado-Sanchez,I, Alvarez-Rios,AI, De Luna-Romero,M, Carrillo-Vico,A, Leal,M, Pacheco,YM Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital HUVR)/ CSIC/ University of Seville, Seville, Spain. Alvarez-Rios,AI Department of Clinical Biochemistry, Virgen del Rocío University Hospital, Seville, Spain. Ramos,R, Cañizares,J Heliopolis Nursing Home, Seville, Spain. Sanbonmatsu-Gámez,S, Pérez-Ruiz,M, Navarro-Marí,JM Servicio de Microbiología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria Ibs Granada, Granada, Spain. Carrillo-Vico,A Department of Medical Biochemistry, Molecular Biology and Immunology, University of Seville, Seville, Spain. Sánchez,B Immunology Service, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. Leal,M Immunovirology section, Viamed Hospital, Santa Ángela de la Cruz, Seville, Spain. Pacheco,YM Laboratory of Immunology, Institute of Biomedicine of Seville (IBiS)/ UGC Clinical, Laboratories, Virgen del Rocío University Hospital, Seville, Spain., This work was supported by grants from the Fondo de Investigación Sanitaria (FIS, PI18/01216), which is co-funded by Fondos Europeos para el Desarrollo Regional (FEDER) and the Junta de Andalucía, Consejería de Economía, Innovación, Ciencia y Empleo (Proyecto de Investigación de Excelencia, CTS2593). The Spanish AIDS Research Network of Excellence also supported this study (RD16/0025/0019). YM.P was supported by the Consejería de Salud y Bienestar Social of Junta de Andalucía through the “Nicolás Monardes” programme (C-0013-2017). |
| بيانات النشر: | BioMed Central Ltd. |
| سنة النشر: | 2019 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Treg, Ki 67, Inflammation, Thymic function, TREC, T-Lymphocytes, regulatory, Antígeno Ki-67, Inflamación, Vacunas contra la influenza, Influenza vaccines, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Nuclear::Ki-67 Antigen, Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes::T-Lymphocyte Subsets::T-Lymphocytes, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation, Medical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Products::Vaccines::Viral Vaccines::Influenza Vaccines |
| الوصف: | Background: Seasonal influenza virus infection is a significant cause of morbimortality in the elderly. However, there is poor vaccine efficacy in this population due to immunosenescence. We aimed to explore several homeostatic parameters in the elderly that could impact influenza vaccine responsiveness. Methods: Subjects (> 60 years old) who were vaccinated against influenza virus were included, and the vaccine response was measured by a haemagglutination inhibition (HAI) test. At baseline, peripheral CD4 and CD8 T-cells were phenotypically characterized. Thymic function and the levels of different inflammation-related biomarkers, including Lipopolysaccharide Binding Protein (LBP) and anti-cytomegalovirus (CMV) IgG antibodies, were also measured. Results: Influenza vaccine non-responders showed a tendency of higher frequency of regulatory T-cells (Tregs) before vaccination than responders (1.49 [1.08-1.85] vs. 1.12 [0.94-1.63], respectively, p = 0.061), as well as higher expression of the proliferation marker Ki67 in Tregs and different CD4 and CD8 T-cell maturational subsets. The levels of inflammation-related biomarkers correlated with the frequencies of different proliferating T-cell subsets and with thymic function (e.g., thymic function with D-dimers, r = - 0.442, p = 0.001). Conclusions: Age-related homeostatic dysregulation involving the proliferation of CD4 and CD8 T-cell subsets, including Tregs, was related to a limited responsiveness to influenza vaccination and a higher inflammatory status in a cohort of elderly people. ; Yes |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1742-4933 |
| Relation: | https://immunityageing.biomedcentral.com/articles/10.1186/s12979-019-0154-y; Herrero-Fernández I, Rosado-Sánchez I, Álvarez-Ríos AI, Galvá MI, De Luna-Romero M, Sanbonmatsu-Gámez S,et al. Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people. Immun Ageing. 2019 Jul 5;16:14.; http://hdl.handle.net/10668/3167; PMC6612162 |
| DOI: | 10.1186/s12979-019-0154-y |
| الاتاحة: | http://hdl.handle.net/10668/3167 https://doi.org/10.1186/s12979-019-0154-y |
| Rights: | open access |
| رقم الانضمام: | edsbas.F36473B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17424933 |
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| DOI: | 10.1186/s12979-019-0154-y |