Academic Journal
Correlation of fetal heart rate dynamics to inflammatory markers and brain-derived neurotrophic factor during pregnancy.
| العنوان: | Correlation of fetal heart rate dynamics to inflammatory markers and brain-derived neurotrophic factor during pregnancy. |
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| المؤلفون: | Mercado, L., Rose, S., Escalona-Vargas, D., Siegel, E.R., Whittington, J.R., Preissl, H., Helmich, M., Eswaran, H. |
| المصدر: | J. Perinat. Med., DOI:10.1515/jpm-2023-0413 (2024) |
| بيانات النشر: | Walter De Gruyter Gmbh |
| سنة النشر: | 2024 |
| المجموعة: | PuSH - Publikationsserver des Helmholtz Zentrums München |
| مصطلحات موضوعية: | Brain-derived Neurotrophic Factor (bdnf), Fetal Heart Rate Variability, Fetal Magnetocardiography, Inflammatory Markers (il-6) |
| الوصف: | OBJECTIVES: This study aims to show the relation between biomarkers in maternal and cord-blood samples and fetal heart rate variability (fHRV) metrics through a non-invasive fetal magnetocardiography (fMCG) technique. METHODS: Twenty-three women were enrolled for collection of maternal serum and fMCG tracings immediately prior to their scheduled cesarean delivery. The umbilical cord blood was collected for measurement of biomarker levels. The fMCG metrics were then correlated to the biomarker levels from the maternal serum and cord blood. RESULTS: Brain-derived neurotrophic factor (BDNF) had a moderate correlation with fetal parasympathetic activity (0.416) and fetal sympathovagal ratios (-0.309;-0.356). Interleukin (IL)-6 also had moderate-sized correlations but with an inverse relationship as compared to BDNF. These correlations were primarily in cord-blood samples and not in the maternal blood. CONCLUSIONS: In this small sample-sized exploratory study, we observed a moderate correlation between fHRV and cord-blood BDNF and IL-6 immediately preceding scheduled cesarean delivery at term. These findings need to be validated in a larger population. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38404246; info:eu-repo/semantics/altIdentifier/wos/001177269800001; info:eu-repo/semantics/altIdentifier/isbn/0300-5577; info:eu-repo/semantics/altIdent |
| DOI: | 10.1515/jpm-2023-0413 |
| الاتاحة: | https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=70027 https://doi.org/10.1515/jpm-2023-0413 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.F327A74D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1515/jpm-2023-0413 |
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