Academic Journal
Structural damage and inflammation on radiographs or magnetic resonance imaging are associated with cortical interruptions on high-resolution peripheral quantitative computed tomography:a study in finger joints of patients with rheumatoid arthritis and healthy subjects
| العنوان: | Structural damage and inflammation on radiographs or magnetic resonance imaging are associated with cortical interruptions on high-resolution peripheral quantitative computed tomography:a study in finger joints of patients with rheumatoid arthritis and healthy subjects |
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| المؤلفون: | Scharmga, A., Geusens, P., Peters, M., van den Bergh, J. P., Loeffen, D., Schoonbrood, T., van Rietbergen, B., Vosse, D., Weijers, R., van Tubergen, A. |
| المصدر: | Scharmga , A , Geusens , P , Peters , M , van den Bergh , J P , Loeffen , D , Schoonbrood , T , van Rietbergen , B , Vosse , D , Weijers , R & van Tubergen , A 2018 , ' Structural damage and inflammation on radiographs or magnetic resonance imaging are associated with cortical interruptions on high-resolution peripheral quantitative computed tomography : a study in finger joints of patients with rheumatoid arthritis and healthy subjects ' , Scandinavian Journal of Rheumatology , vol. 47 , no. 6 , pp. 431-439 . https://doi.org/10.1080/03009742.2018.1424234 |
| سنة النشر: | 2018 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | METACARPOPHALANGEAL JOINTS, BONE EROSION, REPAIR, HAND, ABNORMALITIES, RA |
| الوصف: | Objectives: To study the relationship between structural damage and inflammatory features on magnetic resonance imaging (MRI) or radiography and other risk factors [anti-citrullinated protein antibody (ACPA) and/or rheumatoid factor (RF) seropositivity, hand dominance, disease duration] and the presence or number of cortical interruptions in finger joints on high-resolution peripheral quantitative computed tomography (HR-pQCT). Method: Finger joints of 38 healthy subjects and 39 patients with rheumatoid arthritis (RA) were examined through radiographs, MRI, and HR-pQCT. Radiographs were scored according to the Sharp/van der Heijde (SvH) method; MRI for the presence of cortical interruptions, bone marrow oedema (BMO), and synovitis; and HR-pQCT images for cortical interruptions. Descriptive statistics were calculated and associations examined using generalized estimating equations. Results: Cortical interruptions were found in healthy subjects and patients with RA on HR-pQCT (mean +/- sd 0.33 +/- 0.63 vs 0.38 +/- 0.64 per joint quadrant, respectively, p <0.01). Structural damage on MRI (cortical interruptions) or radiographs (SvH >= 1) was associated with the presence of cortical interruptions on HR-pQCT [odds ratio (OR) 12.4, 95% confidence interval (CI) 7.5-21.4, p <0.01 and OR 4.8, 95% CI 1.9-11.7, respectively, p <0.01]. The presence of BMO or synovitis was associated with more cortical interruptions on HR-pQCT (beta 0.47, 95% CI 0.4-0.6, p <0.01 and beta 1.9, 95% CI 0.6-3.1, p <0.01). In patients with RA, ACPA, and/or RF seropositivity, hand dominance and disease duration were not associated with more cortical interruptions on HR-pQCT. Conclusion: Structural damage and inflammatory features on MRI and radiographs are associated with cortical interruptions on HR-pQCT. No association between other risk factors and cortical interruptions was demonstrated. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1080/03009742.2018.1424234 |
| الاتاحة: | https://cris.maastrichtuniversity.nl/en/publications/5d05f153-e355-4b2b-bb7f-b47bee4add33 https://doi.org/10.1080/03009742.2018.1424234 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F303065C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/03009742.2018.1424234 |
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