Academic Journal
The fate of notch-1 transcript is linked to cell cycle dynamics by activity of a natural antisense transcript
| العنوان: | The fate of notch-1 transcript is linked to cell cycle dynamics by activity of a natural antisense transcript |
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| المؤلفون: | Vujovic, Filip, Rezaei-Lotfi, Saba, Hunter, Neil, Farahani, Ramin M |
| المساهمون: | NIDCR, National Health and Medical Research Council |
| المصدر: | Nucleic Acids Research ; volume 49, issue 18, page 10419-10430 ; ISSN 0305-1048 1362-4962 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2021 |
| الوصف: | A core imprint of metazoan life is that perturbations of cell cycle are offset by compensatory changes in successive cellular generations. This trait enhances robustness of multicellular growth and requires transmission of signaling cues within a cell lineage. Notably, the identity and mode of activity of transgenerational signals remain largely unknown. Here we report the discovery of a natural antisense transcript encoded in exon 25 of notch-1 locus (nAS25) by which mother cells control the fate of notch-1 transcript in daughter cells to buffer against perturbations of cell cycle. The antisense transcript is transcribed at G1 phase of cell cycle from a bi-directional E2F1-dependent promoter in the mother cell where the titer of nAS25 is calibrated to the length of G1. Transmission of the antisense transcript from mother to daughter cells stabilizes notch-1 sense transcript in G0 phase of daughter cells by masking it from RNA editing and resultant nonsense-mediated degradation. In consequence, nAS25-mediated amplification of notch-1 signaling reprograms G1 phase in daughter cells to compensate for the altered dynamics of the mother cell. The function of nAS25/notch-1 in integrating G1 phase history of the mother cell into that of daughter cells is compatible with the predicted activity of a molecular oscillator, slower than cyclins, that coordinates cell cycle within cell lineage. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/nar/gkab800 |
| الاتاحة: | http://dx.doi.org/10.1093/nar/gkab800 http://academic.oup.com/nar/article-pdf/49/18/10419/40538254/gkab800.pdf |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.F30139A5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/nar/gkab800 |
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