Academic Journal
The aggravating role of the ubiquitin–proteasome system in neurodegeneration
| العنوان: | The aggravating role of the ubiquitin–proteasome system in neurodegeneration |
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| المؤلفون: | Ardley, Helen C, Hung, Chao-Chun, Robinson, Philip A |
| المصدر: | FEBS Letters ; volume 579, issue 3, page 571-576 ; ISSN 0014-5793 1873-3468 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2005 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Association of protein inclusions or aggregates within brain tissues of patients with neurodegenerative disorders has been widely reported. These inclusions are commonly characterised both by the presence of ubiquitylated proteins and the sequestration of components of the ubiquitin–proteasome system (UPS). Such observations have led to the proposition that the UPS has a direct role in their formation. Indeed, the presence of ubiquitylated proteins and UPS components in inclusions may reflect unsuccessful attempts by the UPS to remove aggregating proteins. Whether the physical presence of inclusions causes cell death or, conversely, whether they are non‐toxic and their presence reflects a cellular protective mechanism remains highly controversial. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.febslet.2004.12.058 |
| الاتاحة: | http://dx.doi.org/10.1016/j.febslet.2004.12.058 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.febslet.2004.12.058 https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/j.febslet.2004.12.058 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.F2EF0BB5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.febslet.2004.12.058 |
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