Academic Journal
Type 1 CD4 + T-Cell Help Is Required for Induction of Antipeptide Multispecific Cytotoxic T Lymphocytes by a Lipopeptidic Vaccine in Rhesus Macaques
| العنوان: | Type 1 CD4 + T-Cell Help Is Required for Induction of Antipeptide Multispecific Cytotoxic T Lymphocytes by a Lipopeptidic Vaccine in Rhesus Macaques |
|---|---|
| المؤلفون: | Mortara, Lorenzo, Gras-Masse, Helene, Rommens, Corinne, Venet, Alain, Guillet, Jean-Gerard, Bourgault-Villada, Isabelle |
| المصدر: | Journal of Virology ; volume 73, issue 5, page 4447-4451 ; ISSN 0022-538X 1098-5514 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 1999 |
| الوصف: | We have optimized the induction of antiviral cytotoxic T lymphocytes (CTL) in rhesus macaques by a lipopeptide vaccine containing seven peptides from simian immunodeficiency virus (SIV) Nef and Gag proteins and a strong T-helper peptide from tetanus toxoid (TT) that is promiscuous in humans (peptide TT 830-846). Two of the eight immunized macaques showed T-helper (Th) cell proliferation and a specific synthesis of gamma interferon in response to TT 830-846 peptide. They also showed multispecific cytotoxic activity against three to five of the immunizing SIV peptides. These results show the importance of a strong specific type 1 Th response for inducing a multispecific CTL response in vivo, which is essential for the development of an anti-human immunodeficiency virus vaccine. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/jvi.73.5.4447-4451.1999 |
| DOI: | 10.1128/JVI.73.5.4447-4451.1999 |
| الاتاحة: | http://dx.doi.org/10.1128/jvi.73.5.4447-4451.1999 https://journals.asm.org/doi/pdf/10.1128/JVI.73.5.4447-4451.1999 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.F2EE7DCA |
| قاعدة البيانات: | BASE |
| ResultId |
1 |
|---|---|
| Header |
edsbas BASE edsbas.F2EE7DCA 825 3 Academic Journal academicJournal 825.119567871094 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.F2EE7DCA&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => http://dx.doi.org/10.1128/jvi.73.5.4447-4451.1999# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Type 1 CD4 + T-Cell Help Is Required for Induction of Antipeptide Multispecific Cytotoxic T Lymphocytes by a Lipopeptidic Vaccine in Rhesus Macaques
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Mortara%2C+Lorenzo%22">Mortara, Lorenzo</searchLink><br /><searchLink fieldCode="AR" term="%22Gras-Masse%2C+Helene%22">Gras-Masse, Helene</searchLink><br /><searchLink fieldCode="AR" term="%22Rommens%2C+Corinne%22">Rommens, Corinne</searchLink><br /><searchLink fieldCode="AR" term="%22Venet%2C+Alain%22">Venet, Alain</searchLink><br /><searchLink fieldCode="AR" term="%22Guillet%2C+Jean-Gerard%22">Guillet, Jean-Gerard</searchLink><br /><searchLink fieldCode="AR" term="%22Bourgault-Villada%2C+Isabelle%22">Bourgault-Villada, Isabelle</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Journal of Virology ; volume 73, issue 5, page 4447-4451 ; ISSN 0022-538X 1098-5514 ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => American Society for Microbiology ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 1999 ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => We have optimized the induction of antiviral cytotoxic T lymphocytes (CTL) in rhesus macaques by a lipopeptide vaccine containing seven peptides from simian immunodeficiency virus (SIV) Nef and Gag proteins and a strong T-helper peptide from tetanus toxoid (TT) that is promiscuous in humans (peptide TT 830-846). Two of the eight immunized macaques showed T-helper (Th) cell proliferation and a specific synthesis of gamma interferon in response to TT 830-846 peptide. They also showed multispecific cytotoxic activity against three to five of the immunizing SIV peptides. These results show the importance of a strong specific type 1 Th response for inducing a multispecific CTL response in vivo, which is essential for the development of an anti-human immunodeficiency virus vaccine. ) Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1128/jvi.73.5.4447-4451.1999 ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1128/JVI.73.5.4447-4451.1999 ) Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => http://dx.doi.org/10.1128/jvi.73.5.4447-4451.1999<br />https://journals.asm.org/doi/pdf/10.1128/JVI.73.5.4447-4451.1999 ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => https://journals.asm.org/non-commercial-tdm-license ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.F2EE7DCA ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1128/jvi.73.5.4447-4451.1999
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => English
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Type 1 CD4 + T-Cell Help Is Required for Induction of Antipeptide Multispecific Cytotoxic T Lymphocytes by a Lipopeptidic Vaccine in Rhesus Macaques
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Mortara, Lorenzo
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Gras-Masse, Helene
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Rommens, Corinne
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Venet, Alain
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Guillet, Jean-Gerard
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Bourgault-Villada, Isabelle
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 01
[Type] => published
[Y] => 1999
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-locals
[Value] => edsbas
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsbas.oa
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Journal of Virology ; volume 73, issue 5, page 4447-4451 ; ISSN 0022-538X 1098-5514
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |