Academic Journal
Type 1 CD4 + T-Cell Help Is Required for Induction of Antipeptide Multispecific Cytotoxic T Lymphocytes by a Lipopeptidic Vaccine in Rhesus Macaques
| العنوان: | Type 1 CD4 + T-Cell Help Is Required for Induction of Antipeptide Multispecific Cytotoxic T Lymphocytes by a Lipopeptidic Vaccine in Rhesus Macaques |
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| المؤلفون: | Mortara, Lorenzo, Gras-Masse, Helene, Rommens, Corinne, Venet, Alain, Guillet, Jean-Gerard, Bourgault-Villada, Isabelle |
| المصدر: | Journal of Virology ; volume 73, issue 5, page 4447-4451 ; ISSN 0022-538X 1098-5514 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 1999 |
| الوصف: | We have optimized the induction of antiviral cytotoxic T lymphocytes (CTL) in rhesus macaques by a lipopeptide vaccine containing seven peptides from simian immunodeficiency virus (SIV) Nef and Gag proteins and a strong T-helper peptide from tetanus toxoid (TT) that is promiscuous in humans (peptide TT 830-846). Two of the eight immunized macaques showed T-helper (Th) cell proliferation and a specific synthesis of gamma interferon in response to TT 830-846 peptide. They also showed multispecific cytotoxic activity against three to five of the immunizing SIV peptides. These results show the importance of a strong specific type 1 Th response for inducing a multispecific CTL response in vivo, which is essential for the development of an anti-human immunodeficiency virus vaccine. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/jvi.73.5.4447-4451.1999 |
| DOI: | 10.1128/JVI.73.5.4447-4451.1999 |
| الاتاحة: | http://dx.doi.org/10.1128/jvi.73.5.4447-4451.1999 https://journals.asm.org/doi/pdf/10.1128/JVI.73.5.4447-4451.1999 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.F2EE7DCA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/jvi.73.5.4447-4451.1999 |
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