Academic Journal
Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications
| العنوان: | Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications |
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| المؤلفون: | Junling Gu, Kang Geng, Man Guo, Wei Huang, Tingting Zhao, Xuling Li, You-Hua Xu, Yong Xu |
| المصدر: | Evidence-Based Complementary and Alternative Medicine, Vol 2022 (2022) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Other systems of medicine, RZ201-999 |
| الوصف: | Pyroptosis is an inflammatory form of programmed cell death that is dependent on inflammatory caspases, leading to the cleavage of gasdermin D (GSDMD) and increased secretion of interleukin (IL)-1β and IL-18. Recent studies have reported that hyperglycemia-induced cellular stress stimulates pyroptosis, and different signaling pathways have been shown to play crucial roles in regulating pyroptosis. This review summarized and discussed the molecular mechanisms, regulation, and cellular effects of pyroptosis in diabetic microvascular complications, such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. In addition, this review aimed to provide new insights into identifying better treatments for diabetic microvascular complications. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1741-4288 |
| Relation: | http://dx.doi.org/10.1155/2022/5277673; https://doaj.org/toc/1741-4288; https://doaj.org/article/e3e37a1f610a46ab82ff8212445f1a1f |
| DOI: | 10.1155/2022/5277673 |
| الاتاحة: | https://doi.org/10.1155/2022/5277673 https://doaj.org/article/e3e37a1f610a46ab82ff8212445f1a1f |
| رقم الانضمام: | edsbas.F2C7CE2C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17414288 |
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| DOI: | 10.1155/2022/5277673 |