Academic Journal

Large animal ischemic stroke models: replicating human stroke pathophysiology

التفاصيل البيبلوغرافية
العنوان: Large animal ischemic stroke models: replicating human stroke pathophysiology
المؤلفون: Erin E Kaiser, Franklin D West
المصدر: Neural Regeneration Research, Vol 15, Iss 8, Pp 1377-1387 (2020)
بيانات النشر: Wolters Kluwer Medknow Publications
سنة النشر: 2020
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: brain ischemia, clinical translation, gyrencephalic, large animal model, magnetic resonance imaging, stroke, Neurology. Diseases of the nervous system, RC346-429
الوصف: The high morbidity and mortality rate of ischemic stroke in humans has led to the development of numerous animal models that replicate human stroke to further understand the underlying pathophysiology and to explore potential therapeutic interventions. Although promising therapeutics have been identified using these animal models, with most undergoing significant testing in rodent models, the vast majority of these interventions have failed in human clinical trials. This failure of preclinical translation highlights the critical need for better therapeutic assessment in more clinically relevant ischemic stroke animal models. Large animal models such as non-human primates, sheep, pigs, and dogs are likely more predictive of human responses and outcomes due to brain anatomy and physiology that are more similar to humans-potentially making large animal testing a key step in the stroke therapy translational pipeline. The objective of this review is to highlight key characteristics that potentially make these gyrencephalic, large animal ischemic stroke models more predictive by comparing pathophysiological responses, tissue-level changes, and model limitations.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1673-5374
Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=8;spage=1377;epage=1387;aulast=Kaiser; https://doaj.org/toc/1673-5374; https://doaj.org/article/3afe47cb06e14e24bb72a842528ed93e
DOI: 10.4103/1673-5374.274324
الاتاحة: https://doi.org/10.4103/1673-5374.274324
https://doaj.org/article/3afe47cb06e14e24bb72a842528ed93e
رقم الانضمام: edsbas.F2BA5486
قاعدة البيانات: BASE
الوصف
تدمد:16735374
DOI:10.4103/1673-5374.274324