Academic Journal
Large animal ischemic stroke models: replicating human stroke pathophysiology
العنوان: | Large animal ischemic stroke models: replicating human stroke pathophysiology |
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المؤلفون: | Erin E Kaiser, Franklin D West |
المصدر: | Neural Regeneration Research, Vol 15, Iss 8, Pp 1377-1387 (2020) |
بيانات النشر: | Wolters Kluwer Medknow Publications |
سنة النشر: | 2020 |
المجموعة: | Directory of Open Access Journals: DOAJ Articles |
مصطلحات موضوعية: | brain ischemia, clinical translation, gyrencephalic, large animal model, magnetic resonance imaging, stroke, Neurology. Diseases of the nervous system, RC346-429 |
الوصف: | The high morbidity and mortality rate of ischemic stroke in humans has led to the development of numerous animal models that replicate human stroke to further understand the underlying pathophysiology and to explore potential therapeutic interventions. Although promising therapeutics have been identified using these animal models, with most undergoing significant testing in rodent models, the vast majority of these interventions have failed in human clinical trials. This failure of preclinical translation highlights the critical need for better therapeutic assessment in more clinically relevant ischemic stroke animal models. Large animal models such as non-human primates, sheep, pigs, and dogs are likely more predictive of human responses and outcomes due to brain anatomy and physiology that are more similar to humans-potentially making large animal testing a key step in the stroke therapy translational pipeline. The objective of this review is to highlight key characteristics that potentially make these gyrencephalic, large animal ischemic stroke models more predictive by comparing pathophysiological responses, tissue-level changes, and model limitations. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
تدمد: | 1673-5374 |
Relation: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=8;spage=1377;epage=1387;aulast=Kaiser; https://doaj.org/toc/1673-5374; https://doaj.org/article/3afe47cb06e14e24bb72a842528ed93e |
DOI: | 10.4103/1673-5374.274324 |
الاتاحة: | https://doi.org/10.4103/1673-5374.274324 https://doaj.org/article/3afe47cb06e14e24bb72a842528ed93e |
رقم الانضمام: | edsbas.F2BA5486 |
قاعدة البيانات: | BASE |
تدمد: | 16735374 |
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DOI: | 10.4103/1673-5374.274324 |