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Propranolol nanoemulgel: Preparation, in-vitro and ex-vivo characterization for a potential local hemangioma therapy

التفاصيل البيبلوغرافية
العنوان: Propranolol nanoemulgel: Preparation, in-vitro and ex-vivo characterization for a potential local hemangioma therapy
المؤلفون: Abdullah, Taif, Al-Kinani, Khalid
المصدر: Pharmacia, 71(()), 1-12, (2024-01-30)
بيانات النشر: Bulgarian Pharmaceutical Scientific Society
سنة النشر: 2024
المجموعة: Zenodo
مصطلحات موضوعية: clove oil, ex-vivo permeation study, infantile hemangioma, nanoemulgel, propranolol-HCl
الوصف: A lack of safe and effective topical alternatives to oral propranolol HCl (PHCl) hampers optimal management of infantile hemangioma (IH), particularly in complex cases with severe side effects or treatment failures. This study aimed to develop a nanoemulsion gel (NEG) for topical PHCl delivery. A meticulously formulated nanoemulsion (NE) encapsulated with clove oil, Tween 20, and polyethylene glycol 400 emerged as the standout candidate (NE3) due to its exceptional stability, resilience, and favorable drug loading. NE3 exhibited a remarkable globule size of 14.57 nm, a low polydispersity index (PDI) of 0.282, and a stabilizing zeta potential of −19.89 mV. The subsequent formulation of PHCl-NEG displayed desired rheological and spreadability properties for topical application. Ex-vivo skin retention and permeation studies revealed effective PHCl deposition within the dermal layer with minimal systemic exposure. This promising approach offers a potential alternative to oral PHCl, potentially mitigating severe side effects and improving outcomes in complex IH cases.
نوع الوثيقة: article in journal/newspaper
اللغة: unknown
Relation: https://doi.org/10.3897/pharmacia.71.e115330.figurea1; https://doi.org/10.3897/pharmacia.71.e115330.figure8; https://doi.org/10.3897/pharmacia.71.e115330.figure3; https://doi.org/10.3897/pharmacia.71.e115330.figure4; https://doi.org/10.3897/pharmacia.71.e115330.figure5; https://doi.org/10.3897/pharmacia.71.e115330.figure6; https://doi.org/10.3897/pharmacia.71.e115330.figure7; https://doi.org/10.3897/pharmacia.71.e115330.figure1; https://doi.org/10.3897/pharmacia.71.e115330.figure2; https://doi.org/10.3897/pharmacia.71.e115330.figure9; https://doi.org/10.3897/pharmacia.71.e115330.figurea2; https://doi.org/10.3897/pharmacia.71.e115330.figurea3; https://doi.org/10.3897/pharmacia.71.e115330.suppl1; https://doi.org/10.2174/1574891X14666181129115213; https://doi.org/10.1097/ICU.0000000000000591; https://doi.org/10.1016/bs.podrm.2017.02.006; https://doi.org/10.3109/21691401.2016.1163716; https://doi.org/10.3390/nano10050848; https://doi.org/10.1002/slct.201902007; https://doi.org/10.3390/molecules25010112; https://doi.org/10.1016/j.ijpharm.2017.10.005; https://doi.org/10.1155/2016/5754349; https://doi.org/10.1111/jphp.12197; https://doi.org/10.31351/vol29iss1pp41-54; https://doi.org/10.22159/ajpcr.2019.v12i3.31504; https://doi.org/10.1089/dna.2013.2059; https://doi.org/10.3390/pharmaceutics13040579; https://doi.org/10.1080/10408398.2021.1879727; https://doi.org/10.4314/tjpr.v12i2.19; https://doi.org/10.31351/vol27iss2pp93-101; https://doi.org/10.1248/cpb.c21-00997; https://doi.org/10.1097/ANC.0000000000000254; https://doi.org/10.1056/NEJMc0708819; https://doi.org/10.1016/S0140-6736(16)00645-0; https://doi.org/10.1016/j.jconrel.2009.02.013; https://doi.org/10.1097/PRS.0000000000007699; https://doi.org/10.1016/j.sajb.2015.03.192; https://doi.org/10.4274/tjps.62207; https://doi.org/10.12688/f1000research.130749.2; https://doi.org/10.1016/j.aquaculture.2005.02.046; https://doi.org/10.25258/ijddt.13.1.09; https://doi.org/10.5604/17322693.1120990; https://doi.org/10.1097/MPH.0000000000002384; https://doi.org/10.1155/2020/4071818; https://doi.org/10.3109/10717544.2014.907842; https://doi.org/10.31351/vol30iss1pp209-217; https://doi.org/10.31351/vol24iss2pp77-90; https://doi.org/10.51847/1h17TZqgyI; https://doi.org/10.1371/journal.pone.0214544; https://doi.org/10.1016/j.jsps.2023.02.005; https://doi.org/10.5863/1551-6776-25.7.586; https://doi.org/10.1016/j.ejps.2020.105323; https://doi.org/10.1097/01.XPS.0000482654.21247.63; https://doi.org/10.1007/s11596-012-1059-6; https://doi.org/10.3897/pharmacia.71.e115330; oai:zenodo.org:10604816
DOI: 10.3897/pharmacia.71.e115330
الاتاحة: https://doi.org/10.3897/pharmacia.71.e115330
Rights: info:eu-repo/semantics/openAccess ; Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcode
رقم الانضمام: edsbas.F28C3ED2
قاعدة البيانات: BASE
الوصف
DOI:10.3897/pharmacia.71.e115330