Academic Journal
Alveolar mechanics studied by in vivo microscopy imaging through intact pleural space
| العنوان: | Alveolar mechanics studied by in vivo microscopy imaging through intact pleural space |
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| المؤلفون: | Salito, C, Aliverti, A, Mazzuca, E, RIVOLTA, ILARIA, MISEROCCHI, GIUSEPPE ANDREA |
| المساهمون: | Salito, C, Aliverti, A, Rivolta, I, Mazzuca, E, Miserocchi, G |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2014 |
| المجموعة: | Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| مصطلحات موضوعية: | Alveolar mechanic, Compliance, In vivo microscopy imaging, Analysis of Variance, Animal, Bronchoscopy, Extracellular Space, Image Processing, Computer-Assisted, Lung Compliance, Male, Pulmonary Alveoli, Rabbit, Respiratory Mechanic, Physiology, Pulmonary and Respiratory Medicine, Neuroscience (all), Medicine (all) |
| الوصف: | In six male anesthetized, tracheotomized, and mechanically ventilated rabbits we derived indications on alveolar mechanics from in vivo imaging, using a "pleural window" technique (pleural space intact) that allows unrestrained movement of the same subpleural alveoli (N=60) on increasing alveolar pressure from 4 to 8cmH2O. Absolute compliance (Cabs, ratio of change in alveolar surface area to the change in alveolar pressure) was significantly lower in smaller compared to larger alveoli. Specific compliance, Csp, obtained by normalizing Cabs to alveolar surface area, was essentially independent of alveolar size. Both Cabs and Csp were affected by large variability likely reflecting the complex matching between elastic and surface forces. We hypothesize that the relative constancy of Csp might contribute to reduce interregional differences in parenchymal and surface forces in the lung tissue by contributing to assure a uniform stretching in a model of mechanically inter-dependent alveoli. © 2014 Elsevier B.V. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/25058162; info:eu-repo/semantics/altIdentifier/wos/WOS:000343376100007; volume:202; firstpage:44; lastpage:49; numberofpages:6; journal:RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY; http://hdl.handle.net/10281/100358; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84906096458; http://www.elsevier.com/inca/publications/store/6/2/2/7/2/7/ |
| DOI: | 10.1016/j.resp.2014.07.012 |
| الاتاحة: | http://hdl.handle.net/10281/100358 https://doi.org/10.1016/j.resp.2014.07.012 http://www.elsevier.com/inca/publications/store/6/2/2/7/2/7/ |
| رقم الانضمام: | edsbas.F26C8374 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.resp.2014.07.012 |
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