Academic Journal

Systematic Review and Meta-Analysis on Randomized Controlled Trials on Efficacy and Safety of Panax Notoginseng Saponins in Treatment of Acute Ischemic Stroke

التفاصيل البيبلوغرافية
العنوان: Systematic Review and Meta-Analysis on Randomized Controlled Trials on Efficacy and Safety of Panax Notoginseng Saponins in Treatment of Acute Ischemic Stroke
المؤلفون: Liu-ding Wang, Zhen-min Xu, Xiao Liang, Wen-ran Qiu, Shao-jiao Liu, Ling-ling Dai, Ye-fei Wang, Chun-yan Guo, Xiang-hua Qi, Jian Wang, Yan-bing Ding, Yun-ling Zhang, Xing Liao
المصدر: Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
بيانات النشر: Hindawi Limited
سنة النشر: 2021
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: Other systems of medicine, RZ201-999
الوصف: Importance. Panax Notoginseng Saponins (PNS) are proven to have antiplatelet effects in patients with acute ischemic stroke (AIS). Objective. To assess the efficacy and safety of PNS on antiplatelet therapy in the treatment of AIS. Methods. We searched 7 literature databases and 2 clinical studies databases for randomized controlled studies (RCTs) evaluating PNS as an adjuvant therapy for AIS. Relevant studies were retrieved and screened, and data were extracted independently by two reviewers. The quality of the included studies was assessed using the Cochrane Risk Assessment Tool. Meta-analysis was carried out with the Rev Man 5.4 software. Results. Of 8267 records identified, 43 RCTs met our inclusion criteria (n = 4170 patients). Patients assigned to PNS with conventional treatments (CTs) had improved functional independence at 90 days compared with those assigned to CTs alone (RR = 1.87, 95% CI = 1.37, to 2.55, P<0.0001). Patients who received PNS combined with CTs showed significantly high improvements in neurological function among individuals with AIS on the neurologic deficit score (NDS) (MDCSS = −5.71, 95% CI = −9.55 to −1.87, P=0.004; MDNIHSS = −3.94, 95% CI = −5.65 to −2.23, P<0.00001). The results also showed PNS contributed to a betterment in activities of daily living (ADL) on the Barthel index (MDday10 BI = 4.86, 95% CI = 2.18, to 7.54, P<0.00001; MDday 14 BI = 13.92, 95% CI = 11.46 to 16.38, P<0.00001; MDday 28 BI = 7.16, 95% CI = 0.60, to 13.72, P<0.00001). In addition, PNS, compared with CTs alone, could significantly improve overall response rate (ORR) (RRNIHSS = 1.20, 95% CI = 1.16, to 1.24, P<0.00001; RRCSS = 1.15, 95% CI = 1.08, to 1.24, P<0.0001), hemorheological parameters, maximum platelet aggregation rate (MPAR) (MD = −6.82, 95% CI = −9.62 to −4.02, P<0.00001), platelet parameters (MDPLT = 4.85, 95% CI = 1.82 to 7.84, P=0.002; MDMPV = −0.79, 95% CI = −1.09 to −0.48, P<0.00001), and serum CD62P (MD = −0.21, 95% CI = −0.29 to −0.13, P<0.00001). The incidence ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1741-427X
1741-4288
Relation: http://dx.doi.org/10.1155/2021/4694076; https://doaj.org/toc/1741-427X; https://doaj.org/toc/1741-4288; https://doaj.org/article/ebb811441a0f407e9b1ce87d2208cf6b
DOI: 10.1155/2021/4694076
الاتاحة: https://doi.org/10.1155/2021/4694076
https://doaj.org/article/ebb811441a0f407e9b1ce87d2208cf6b
رقم الانضمام: edsbas.F2564A44
قاعدة البيانات: BASE
الوصف
تدمد:1741427X
17414288
DOI:10.1155/2021/4694076