Academic Journal
The results of concentration of care: surgical outcomes of neuroblastoma in the Netherlands
| العنوان: | The results of concentration of care: surgical outcomes of neuroblastoma in the Netherlands |
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| المؤلفون: | Steeg, A.F.W. van der, Jans, M., Tytgat, G., Fiocco, M.F., Ven, C. van de, Scheltinga, C.E.J.T. van, Pieters, R., Noesel, M.M. van, Dijk, A.H. van, Hulsker, C.C.C., Wijnen, M.H.W.A. |
| المصدر: | European Journal of Surgical Oncology |
| سنة النشر: | 2023 |
| المجموعة: | Leiden Repository (Leiden University) |
| مصطلحات موضوعية: | Pediatric oncology, Neuroblastoma, Concentration of care, Surgery, Complications |
| الوصف: | Introduction. In the Netherlands pediatric oncological care for solid tumours is concentrated in one centre since November 2014. One of the most frequently diagnosed solid non-brain tumours in children is the neuroblastoma. Results of surgical treatment of neuroblastoma since the start of this centralization are presented and compared to a historic cohort. Methods. The new national cohort of neuroblastoma (n = 111) consists of all consecutive patients treated be-tween January 1st, 2015 and April 1st, 2021. The historic neuroblastoma cohort consists of all operated neuroblastoma patients in the Netherlands between 1998 and 2014 (n = 244). Intra-operative compli-cations and surgical outcome were registered. Post-operative complications were divided in short (<30 days after surgery) and long term (>30 days). The severity of complications was graded using the Clavien Dindo Classification (CDC) system. Results. Intraoperative outcomes showed significant differences in favour of the new cohort with less blood loss (p < 0.001), fewer vascular complications (p < 0.001) and shorter duration of surgery (p < 0.001). Short term complications were comparable in numbers, but significantly more patients had CDC grade 3/ 4/5 complications in the historic cohort (p = 0.005). Long term complications did not differ. Estimated overall survival showed a better survival in the new cohort (log rank 0.022). Conclusion. Centralization of care for neuroblastoma patients has led to a significant improvement of both intraoperative outcomes and short term complications. (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). ; Development and application of statistical models for medical scientific research |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://www.ejso.com/article/S0748-7983(22)00697-7/fulltext; lumc-id: 185782550; https://hdl.handle.net/1887/3748600 |
| DOI: | 10.1016/j.ejso.2022.10.005 |
| الاتاحة: | https://hdl.handle.net/1887/3748600 https://www.ejso.com/article/S0748-7983(22)00697-7/fulltext https://doi.org/10.1016/j.ejso.2022.10.005 |
| رقم الانضمام: | edsbas.F2435D4C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ejso.2022.10.005 |
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