Academic Journal
Disseminated Cryptococcus Neoformans Infection in a Renal Transplant Patient
| العنوان: | Disseminated Cryptococcus Neoformans Infection in a Renal Transplant Patient |
|---|---|
| المؤلفون: | Tangirala, Praharsha, Mathew, Trina, Lee, Jack, Arispe, Ryan, Yalamanchili, Harika, Sengodan, Mohan, Machaiah, Madhrira, Balamuthusamy, Saravanan |
| سنة النشر: | 2022 |
| المجموعة: | UNTHSC Scholarly Repository (University. of North Texas Health Science Center) |
| الوصف: | Background: Cryptoccocus Neoformans is a fungus mainly found in the environment that infects humans via inhalation and usually affects the lungs and central nervous system. Most people remain asymptomatic; however, immunocompromised patients are most susceptible to this pathogen, particularly HIV/AIDs patients. We present a case of a renal transplant patient with disseminated Cryptococcus Neoformans infection. Case Presentation: A 71 y/o female presents to the emergency department for further evaluation of a fever of unknown origin that has been going on for 6 days. Outpatient workup was initiated by the transplant service; however, due to persistently high fevers she was admitted for further workup and management. Patient reports that her fevers mainly occur at night and reach a maximum of 104-105 F. In the morning the fever decreases to 102 F with Tylenol. Denies any other significant symptoms, recent travel, sick contacts, alcohol, tobacco, or drug use. Past history is significant for CKD due to IgA nephropathy with renal transplant 2.5 years ago. Patient is currently on a chronic immunosuppressive regimen of Mycophenolate and Tacrolimus and infection prophylaxis with TMP-SMX and Valganciclovir. Upon admission, vitals were within normal limits and physical exam was unremarkable. Labs showed negative urinalysis, influenza, COVID-19, and rapid strep antigen test. Lactic acid, magnesium, coagulation studies, TSH, and troponin were all within normal limits. BUN was elevated at 32 and Creatinine at 1.8. White blood cell count was decreased at 2.8k, hemoglobin decreased at 10.9, and hematocrit decreased at 34.2. Chest X-ray showed nodular opacifications involving the right mid to upper lung, possibly masses or mass like infiltrates. Malignancy at this point was high on the differential. CT of the chest was then obtained, which revealed a right upper lobe mass and bilateral pulmonary lymph node involvement that was concerning for metastatic disease. On admission day 2, a CT guided lung biopsy was done. Preliminary ... |
| نوع الوثيقة: | text still image |
| اللغة: | English |
| Relation: | https://hdl.handle.net/20.500.12503/30846 |
| الاتاحة: | https://hdl.handle.net/20.500.12503/30846 |
| رقم الانضمام: | edsbas.F1F3DA |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |