Academic Journal
Influence of bezafibrate on hepatic cholesterol metabolism in gallstone patients: Reduced activity of cholesterol 7α-hydroxylase
| العنوان: | Influence of bezafibrate on hepatic cholesterol metabolism in gallstone patients: Reduced activity of cholesterol 7α-hydroxylase |
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| المؤلفون: | Ståhlberg, Dagny, Reihnér, Eva, Rudling, Mats, Berglund, Lars, Einarsson, Kurt, Angelin, Bo |
| المصدر: | Hepatology ; volume 21, issue 4, page 1025-1030 ; ISSN 0270-9139 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 1995 |
| الوصف: | Bezafibrate is a hypolipidemic fibric acid derivative known to induce cholesterol supersaturation of bile. To characterize its effects on hepatic cholesterol metabolism, 31 normolipidemic, normal-weight patients with gallstones undergoing cholecystectomy were studied. Eleven patients (5 men) were randomized to treatment with bezafibrate, 200 mg three times daily for 4 weeks before operation; the remaining 20 patients (5 men) served as nontreatment controls. At operation, a liver biopsy specimen was obtained under standardized conditions and several important parameters of cholesterol metabolism were assayed. Bezafibrate treatment lowered total plasma cholesterol and triglycerides 30% and 37%, respectively. The hepatic cholesterol 7α-hydroxylasé activity was reduced by ≈60% in the bezafibrate treated patients compared with the controls, whereas the acyl-coenzyme A: cholesterol acyltransferase (ACAT) activity was similar in the two groups. The total 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity was increased twofold in the treated patients, whereas the active enzyme remained about the same as in the controls. The low-density lipoprotein (LDL) receptor binding activity was unaffected by the treatment. Bezafibrate treatment significantly reduces cholesterol 7α-hydroxylase activity, and it is suggested that this may play an important role for the development of supersaturated bile during such therapy. (Hepatology 1995; 21:1025-1030.) |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/hep.1840210421 |
| الاتاحة: | https://doi.org/10.1002/hep.1840210421 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.1840210421 https://journals.lww.com/01515467-199504000-00020 |
| Rights: | http://doi.wiley.com/10.1002/tdm_license_1.1 |
| رقم الانضمام: | edsbas.F1E45842 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/hep.1840210421 |
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