Academic Journal
The role of sphingosine‐1‐phosphate in skeletal muscle: Physiology, mechanisms, and clinical perspectives
| العنوان: | The role of sphingosine‐1‐phosphate in skeletal muscle: Physiology, mechanisms, and clinical perspectives |
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| المؤلفون: | Cordeiro, André V., Silva, Vagner R. R., Pauli, José R., da Silva, Adelino S. R., Cintra, Dennys E., Moura, Leandro P., Ropelle, Eduardo R. |
| المساهمون: | Fundação de Amparo à Pesquisa do Estado de São Paulo |
| المصدر: | Journal of Cellular Physiology ; volume 234, issue 7, page 10047-10059 ; ISSN 0021-9541 1097-4652 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2018 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Sphingolipids were discovered more than a century ago and were simply considered as a class of cell membrane lipids for a long time. However, after the discovery of several intracellular functions and their role in the control of many physiological and pathophysiological conditions, these molecules have gained much attention. For instance, the sphingosine‐1‐phosphate (S1P) is a circulating bioactive sphingolipid capable of triggering strong intracellular reactions through the family of S1P receptors (S1PRs) spread in several cell types and tissues. Recently, the role of S1P in the control of skeletal muscle metabolism, atrophy, regeneration, and metabolic disorders has been widely investigated. In this review, we summarized the knowledge of S1P and its effects in skeletal muscle metabolism, highlighting the role of S1P/S1PRs axis in skeletal muscle regeneration, fatigue, ceramide accumulation, and insulin resistance. Finally, we discussed the physical exercise role in S1P/S1PRs signaling in skeletal muscle cells, and how this nonpharmacological strategy may be prospective for future investigations due to its ability to increase S1P levels. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/jcp.27870 |
| الاتاحة: | http://dx.doi.org/10.1002/jcp.27870 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjcp.27870 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcp.27870 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jcp.27870 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.F1BBAC4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jcp.27870 |
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