Academic Journal
Gastric intestinal metaplasia as detected by a monoclonal antibody is highly associated with gastric adenocarcinoma
| العنوان: | Gastric intestinal metaplasia as detected by a monoclonal antibody is highly associated with gastric adenocarcinoma |
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| المؤلفون: | Mirza, Z K, Das, K K, Slate, J, Mapitigama, R N, Amenta, P S, Griffel, L H, Ramsundar, L, Watari, J, Yokota, K, Tanabe, H, Sato, T, Kohgo, Y, Das, K M |
| بيانات النشر: | BMJ Publishing Group Ltd |
| سنة النشر: | 2003 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Stomach |
| الوصف: | Background: Some forms of gastric intestinal metaplasia (GIM) may be precancerous but the cellular phenotype that predisposes to gastric carcinogenesis is not well characterised. Mucin staining, as a means of differentiating GIM, is difficult. A monoclonal antibody, mAb Das-1 (initially called 7E 12 H 12 ), whose staining is phenotypically specific to colon epithelium, was used to investigate this issue. Methods: Using mAb Das-1, by a sensitive immunoperoxidase assay, we examined histologically confirmed GIM specimens from two countries, the USA and Japan. A total of 150 patients comprised three groups: group A, GIM (fields away from the cancer area) from patients with gastric carcinoma (n=60); group B, GIM with chronic gastritis (without gastric carcinoma) (n=72); and group C, chronic gastritis without GIM (n=18). Results: Fifty six of 60 (93%) patients with GIM (both goblet and non-goblet metaplastic cells) from group A reacted intensely with mAb Das-1. Cancer areas from the same 56 patients also reacted. In contrast, 25/72 (35%) samples of GIM from patients in group B reacted with mAb Das-1 (group A v B, p<0.0001). None of the samples from group C reacted with the mAb. Conclusions: Reactivity of mAb Das-1 is clinically useful to simplify and differentiate the phenotypes of GIM. The colonic phenotype of GIM, as identified by mAb Das-1, is strongly associated with gastric carcinoma. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://gut.bmj.com/cgi/content/short/52/6/807; http://dx.doi.org/10.1136/gut.52.6.807 |
| DOI: | 10.1136/gut.52.6.807 |
| الاتاحة: | http://gut.bmj.com/cgi/content/short/52/6/807 https://doi.org/10.1136/gut.52.6.807 |
| Rights: | Copyright (C) 2003, BMJ Publishing Group |
| رقم الانضمام: | edsbas.F18C3B07 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/gut.52.6.807 |
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