Academic Journal
Somatic evolution and global expansion of an ancient transmissible cancer lineage
| العنوان: | Somatic evolution and global expansion of an ancient transmissible cancer lineage |
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| المؤلفون: | Baez-Ortega, Adrian, Gori, Kevin, Strakova, Andrea, Allen, Janice L., Allum, Karen M., Bansse-Issa, Leontine, Bhutia, Thinlay N., Bisson, Jocelyn L., Briceño, Cristóbal, Castillo Domracheva, Artemio, Corrigan, Anne M., Cran, Hugh R., Crawford, Jane T., Davis, Eric, de Castro, Karina F., B. de Nardi, Andrigo, de Vos, Anna P., Delgadillo Keenan, Laura, Donelan, Edward M., Espinoza Huerta, Adela R., Faramade, Ibikunle A., Fazil, Mohammed, Fotopoulou, Eleni, Fruean, Skye N., Gallardo-Arrieta, Fanny, Glebova, Olga, Gouletsou, Pagona G., Häfelin Manrique, Rodrigo F., Henriques, Joaquim J. G. P., Horta, Rodrigo S., Ignatenko, Natalia, Kane, Yaghouba, King, Cathy, Koenig, Debbie, Krupa, Ada, Kruzeniski, Steven J., Kwon, Young-Mi, Lanza-Perea, Marta, Lazyan, Mihran, Lopez Quintana, Adriana M., Losfelt, Thibault, Marino, Gabriele, Martínez Castañeda, Simón, Martínez-López, Mayra F., Meyer, Michael, Migneco, Edward J., Nakanwagi, Berna, Neal, Karter B., Neunzig, Winifred, Ní Leathlobhair, Máire |
| المساهمون: | Wellcome, Leverhulme Trust, Kennel Club Charitable Trust |
| المصدر: | Science ; volume 365, issue 6452 ; ISSN 0036-8075 1095-9203 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS) |
| سنة النشر: | 2019 |
| الوصف: | It's a dog's life Canine transmissible venereal tumor is one of the few cancer lineages that is transferred among individuals through contact. It arose millennia ago and has been evolving independently from its hosts ever since. Baez-Ortega et al. looked at the phylogenetic history of the cancer and describe several distinctive mutational patterns (see the Perspective by Maley and Shibata). Most notably, both positive and negative selection show only weak or distant signals. This suggests that the main driver of the lineage's evolution is neutral genetic drift. Understanding the influence of drift may reshape how we think about long-term cancer evolution. Science , this issue p. eaau9923 ; see also p. 440 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1126/science.aau9923 |
| الاتاحة: | http://dx.doi.org/10.1126/science.aau9923 https://syndication.highwire.org/content/doi/10.1126/science.aau9923 https://www.science.org/doi/pdf/10.1126/science.aau9923 |
| رقم الانضمام: | edsbas.F13BEF77 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1126/science.aau9923 |
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