Academic Journal
The Effect of Latent Toxoplasma gondii Infection on the Immune Response in HIV-Infected Patients
| العنوان: | The Effect of Latent Toxoplasma gondii Infection on the Immune Response in HIV-Infected Patients |
|---|---|
| المؤلفون: | Ondrej Beran, Petr Kodym, Marek Maly, Alzbeta Davidova, Gabriela Reinvartova, David Jilich, Michal Holub, Hanus Rozsypal |
| المصدر: | BioMed Research International, Vol 2015 (2015) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2015 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine |
| الوصف: | A relationship between latent toxoplasmosis and the immune system during HIV disease is poorly understood. Therefore, the aim of this follow-up study was to characterize immunological parameters in HIV-infected patients with latent toxoplasmosis and noninfected individuals. A total of 101 HIV-infected patients were enrolled in the study. The patients were classified into two groups based on anti-Toxoplasma gondii antibodies: a group of 55 toxoplasma-positive persons (TP) and a group of 46 toxoplasma-negative persons (TN). Absolute counts of several lymphocyte subsets decreased in the TP group, namely, T cells (p=0.007), B cells (p=0.002), NK cells (p=0.009), CD4 T cells (p=0.028), and CD8 T cells (p=0.004). On the other hand, the percentage of CD8 T cells expressing CD38 and HLA-DR significantly increased during the follow-up in the TP group (p=0.003, p=0.042, resp.) as well as the intensity of CD38 and HLA-DR expression (MFI) on CD8 T cells (p=0.001, p=0.057, resp.). In the TN group, analysis of the kinetics of immunological parameters revealed no significant changes over time. In conclusion, the results suggest that latent T. gondii infection modulates the immune response during HIV infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2314-6133 2314-6141 |
| Relation: | http://dx.doi.org/10.1155/2015/271842; https://doaj.org/toc/2314-6133; https://doaj.org/toc/2314-6141; https://doaj.org/article/dbe418c311c8438eb7eb325dd0a67e57 |
| DOI: | 10.1155/2015/271842 |
| الاتاحة: | https://doi.org/10.1155/2015/271842 https://doaj.org/article/dbe418c311c8438eb7eb325dd0a67e57 |
| رقم الانضمام: | edsbas.F131014 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23146133 23146141 |
|---|---|
| DOI: | 10.1155/2015/271842 |