Academic Journal
Epithelial Mesenchymal Transition and Immune Response in Metaplastic Breast Carcinoma
| العنوان: | Epithelial Mesenchymal Transition and Immune Response in Metaplastic Breast Carcinoma |
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| المؤلفون: | González-Martínez, Silvia, Pérez-Mies, Belén, Pizarro, David, Caniego-Casas, Tamara, Cortés Castan, Javier, Palacios, José |
| المساهمون: | Institut Català de la Salut, González-Martínez S Clinical Researcher, Hospital Ramón y Cajal, 28034 Madrid, Spain. Pérez-Mies B, Palacios J Department of Pathology, Hospital Ramón y Cajal, 28034 Madrid, Spain. Institute Ramón y Cajal for Health Research (IRYCIS), 28034 Madrid, Spain. CIBER-ONC, Instituto de Salud Carlos III, 28029 Madrid, Spain. Faculty of Medicine, University of Alcalá de Henares, Alcalá de Henares, 28801 Madrid, Spain. Pizarro D, Caniego-Casas T Institute Ramón y Cajal for Health Research (IRYCIS), 28034 Madrid, Spain. Cortés J CIBER-ONC, Instituto de Salud Carlos III, 28029 Madrid, Spain. Faculty of Biomedical and Health Sciences, Department of Medicine, Universidad Europea de Madrid, 28670 Madrid, Spain. International Breast Cancer Center (IBCC), Quironsalud Group, 08017 Barcelona, Spain. Medica Scientia Innovation Research, 08007 Barcelona, Spain. Medica Scientia Innovation Research, Ridgewood, NJ 07450, USA. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | MDPI |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Mama - Càncer - Tractament, Cèl·lules - Transformació, Fisiologia cel·lular, PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Transdifferentiation::Epithelial-Mesenchymal Transition, Other subheadings::Other subheadings::/drug effects, DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms, Other subheadings::Other subheadings::Other subheadings::/immunology, FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::transdiferenciación celular::transición epiteliomesenquimatosa, Otros calificadores::Otros calificadores::/efectos de los fármacos, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama, Otros calificadores::Otros calificadores::Otros calificadores::/inmunología |
| الوصف: | Transició epitelial-mesenquimal; Carcinoma de mama metaplàstic ; Transición epitelio-mesenquimatosa; Carcinoma de mama metaplasico ; Epithelial-mesenchymal transition; Metaplastic breast carcinoma ; Metaplastic breast carcinoma (MBC) is a heterogeneous group of infrequent triple negative (TN) invasive carcinomas with poor prognosis. MBCs have a different clinical behavior from other types of triple negative breast cancer (TNBC), being more resistant to standard chemotherapy. MBCs are an example of tumors with activation of epithelial–mesenchymal transition (EMT). The mechanisms involved in EMT could be responsible for the increase in the infiltrative and metastatic capacity of MBCs and resistance to treatments. In addition, a relationship between EMT and the immune response has been seen in these tumors. In this sense, MBC differ from other TN tumors showing a lower number of tumor-infiltrating lymphocytes (TILS) and a higher percentage of tumor cells expressing programmed death-ligand 1 (PD-L1). A better understanding of the relationship between the immune system and EMT could provide new therapeutic approaches in MBC. ; This review was funded by grants from the Instituto de Salud Carlos III (ISCIII) (PI19/01331) and CIBERONC (CB16/12/00316 and CB16/12/00449), co-financed by the European Development Regional Fund. ‘A way to achieve Europe’ (FEDER), and by the Spanish Association Against Cancer Scientific Foundation (Grupos Coordinados Traslacionales aecc 2018). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-0-00-676513-4 0-00-676513-0 |
| تدمد: | 1422-0067 |
| Relation: | International Journal of Molecular Sciences;22(14); https://doi.org/10.3390/ijms22147398; info:eu-repo/grantAgreement/ES/PE2013-2016/CB16%2F12%2F00449; González-Martínez S, Pérez-Mies B, Pizarro D, Caniego-Casas T, Cortés J, Palacios J. Epithelial Mesenchymal Transition and Immune Response in Metaplastic Breast Carcinoma. Int J Mol Sci. 2021 Jul;22(14):7398.; https://hdl.handle.net/11351/6937; 000676513000001 |
| DOI: | 10.3390/ijms22147398 |
| الاتاحة: | https://hdl.handle.net/11351/6937 https://doi.org/10.3390/ijms22147398 |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F0FF195F |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9780006765134 0006765130 |
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| تدمد: | 14220067 |
| DOI: | 10.3390/ijms22147398 |