Academic Journal
Pharmacokinetics of indomethacin in sheep after intravenous and intramuscular administration
| العنوان: | Pharmacokinetics of indomethacin in sheep after intravenous and intramuscular administration |
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| المؤلفون: | Vinagre, B., RodrÍguez, C., San AndrÉs, M. I., Boggio, J. C., San AndrÉs, M. D., Encinas, T. |
| المصدر: | Journal of Veterinary Pharmacology and Therapeutics ; volume 21, issue 4, page 309-314 ; ISSN 0140-7783 1365-2885 |
| بيانات النشر: | Wiley |
| سنة النشر: | 1998 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The pharmacokinetics of indomethacin (1mg/kg) was determined in six adult sheep after intravenous (i.v.) and intramuscular (i.m.) injection. Plasma concentrations were maintained within the therapeutic range (0.3–3.0 μg/mL) from 5 to 50 min after i.v. and from 5 to 60–90 min after i.m. administration. After two trials, indomethacin best fitted an open two‐compartment model. The mean (±SD) volumes of distribution at steady state ( V d ss ) were 4.10 ± 1.40 and 4.21 ± 1.93 L/kg and the mean clearance values ( C l B ) were 0.17 ± 0.06 and 0.22 ± 0.12 L/h.kg for i.v. and i.m. routes, respectively. The elimination phase half‐lives did not show any significant difference between routes of injection ( t ½β = 17.4 ± 4.6 and 21.25 ± 4.44 h, i.v. and i.m. respectively). After i.m. administration, plasma maximum concentration ( C max = 1.10 ± 0.68 μg/mL) was reached 10 min after dosing; the absorption phase was fast ( K ab = 26 ± 18 h ‐1 ) and short ( t ½ab = 2.33 ± 1.51 min) and the mean bioavailability was 91.0 ± 32.8%, although there was considerable interanimal variation. In some individuals, bioavailability was higher than 100%. This fact combined with the slower elimination phase after i.m. than after i.v. administration, could be related with enterohepatic recycling. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1046/j.1365-2885.1998.00146.x |
| الاتاحة: | http://dx.doi.org/10.1046/j.1365-2885.1998.00146.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2885.1998.00146.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2885.1998.00146.x https://onlinelibrary.wiley.com/doi/full-xml/10.1046/j.1365-2885.1998.00146.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.F0C90F3A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1046/j.1365-2885.1998.00146.x |
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