Glycosylphosphatidylinositol-anchored H-2Db molecules are defective in antigen processing and presentation to cytotoxic T lymphocytes.

التفاصيل البيبلوغرافية
العنوان:	Glycosylphosphatidylinositol-anchored H-2Db molecules are defective in antigen processing and presentation to cytotoxic T lymphocytes.
المؤلفون:	Cariappa, A, Flyer, D C, Rollins, C T, Roopenian, D C, Flavell, R A, Brown, D, Waneck, G L
المصدر:	Faculty Research 1990 - 1999
بيانات النشر:	The Mouseion at the JAXlibrary
سنة النشر:	1996
المجموعة:	The Jackson Laboratory: The Mouseion at the JAXlibrary
مصطلحات موضوعية:	Antigen-Presentation, Cells-Cultured, Cytotoxicity-Immunologic, Glycosylphosphatidylinositols: an, ph, H-2-Antigens: an, Male, Mice, Mice-Inbred-CBA, Mice-Inbred-C3H, Mice-Inbred-C57BL, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes-Cytotoxic: im, Transfection
الوصف:	Glycosylphosphatidylinositol-anchored (GPI)-Db molecules are defective in mediating cytotoxic T lymphocytes (CTL) lysis of transfected lymphoma cells, compared to their transmembrane (TM) counterpart. This defect is manifest when antigenic peptide must be processed and presented through the endogenous pathway. These same transfectants can be lysed by allospecific CTL, or by antigen-specific Db-restricted CTL when pulsed with appropriate exogenous synthetic peptide, demonstrating that they can bind and present peptide for CTL-mediated lympholysis. The defect apparently results from differences between GPI-Db and TM-Db assembly and transport, or from differences in membrane topology that affect CD8+ CTL recognition of major histocompatibility complex/peptide complex.
نوع الوثيقة:	text
اللغة:	unknown
Relation:	https://mouseion.jax.org/stfb1990_1999/827; http://www3.interscience.wiley.com/journal/112146852/abstract
الاتاحة:	https://mouseion.jax.org/stfb1990_1999/827 http://www3.interscience.wiley.com/journal/112146852/abstract
رقم الانضمام:	edsbas.F088CF50
قاعدة البيانات:	BASE

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الوصف
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