Academic Journal
Primary Cilia as a Tumor Marker in Pituitary Neuroendocrine Tumors
| العنوان: | Primary Cilia as a Tumor Marker in Pituitary Neuroendocrine Tumors |
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| المؤلفون: | Martínez Hernández, Rebeca, Serrano Somavilla, Ana, Fernández Contreras, Raul, Sanchez Guerrero, Cristina, Sánchez de la Blanca, Nuria, Sacristán Gómez, Pablo, Sebastian Valles, Fernando, Sampedro Núñez, Miguel Antonio, Fraga Fernández, Javier Germán, Calatayud, María, Vicente, Almudena, García de Casasola, Gonzalo, Sanz García, Ancor, Araujo Castro, Marta, Ruz Caracuel, Ignacio, Puig Domingo, Manel, Marazuela Azpiroz, Mónica |
| المساهمون: | UAM. Departamento de Medicina |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2024 |
| المجموعة: | Universidad Autónoma de Madrid (UAM): Biblos-e Archivo |
| مصطلحات موضوعية: | ciliogenesis, pituitary neuroendocrine tumors, primary cilia, tumor marker, Medicina |
| الوصف: | Pituitary neuroendocrine tumors (PitNETs) account for approximately 15% of all intracranial neoplasms. Although they usually appear to be benign, some tumors display worse behavior, displaying rapid growth, invasion, refractoriness to treatment, and recurrence. Increasing evidence supports the role of primary cilia (PC) in regulating cancer development. Here, we showed that PC are significantly increased in PitNETs and are associated with increased tumor invasion and recurrence. Serial electron micrographs of PITNETs demonstrated different ciliation phenotypes (dot-like versus normal-like cilia) that represented PC at different stages of ciliogenesis. Molecular findings demonstrated that 123 ciliary-associated genes (eg, doublecortin domain containing protein 2, Sintaxin-3, and centriolar coiled-coil protein 110) were dysregulated in PitNETs, representing the upregulation of markers at different stages of intracellular ciliogenesis. Our results demonstrate, for the first time, that ciliogenesis is increased in PitNETs, suggesting that this process might be used as a potential target for therapy in the future ; This work was supported by the following grants: Proyectos de Investigación en Salud PI19/00584, PI22/01404 and PMP22/00021 (funded by Instituto de Salud Carlos III), iTIRONETdP2022/BMD7379 (funded by Comunidad de Madrid), Research project IPI/2022/N5 (funded by Sociedad de Endocrinología, Nutrici on y Diabetes de la Comunidad de Madrid-SENDIMAD), and co-financed by FEDER funds to MM and RMH, as well as by Contratos Predoctorales de Formaci on en Investigaci on en Salud (FI20/00035 to PSG and FI23/00052 to NSB). The funders played no role in the study design, data collection, data analysis, interpretation, or writing of the report |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Modern Pathology; https://doi.org/10.1016/j.modpat.2024.100475; Gobierno de España. PI19/00584; Gobierno de España. PI22/01404; Gobierno de España. PMP22/00021; Comunidad de Madrid. iTIRONETdP2022/ BMD7379; Comunidad de Madrid. IPI/2022/N5; Modern Pathology 37.5 (2024): 100475-100475; 0893-3952 (print); 1530-0285 (online); http://hdl.handle.net/10486/714983; 100475; 37 |
| DOI: | 10.1016/j.modpat.2024.100475 |
| الاتاحة: | http://hdl.handle.net/10486/714983 https://doi.org/10.1016/j.modpat.2024.100475 |
| Rights: | © 2024 The Author(s) ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; Reconocimiento – NoComercial – SinObraDerivada ; openAccess |
| رقم الانضمام: | edsbas.F07FB193 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.modpat.2024.100475 |
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