Academic Journal
Resolution of sickle cell disease–associated inflammation and tissue damage with 17R-resolvin D1
| العنوان: | Resolution of sickle cell disease–associated inflammation and tissue damage with 17R-resolvin D1 |
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| المؤلفون: | Matte A., Recchiuti A., Federti E., Koehl B., Mintz T., Nemer W. E., Tharaux P. -L., Brousse V., Andolfo I., Lamolinara A., Weinberg O., Siciliano A., Norris P. C., Riley I. R., Iolascon A., Serhan C. N., Brugnara C., De Franceschi L. |
| المساهمون: | Matte, A., Recchiuti, A., Federti, E., Koehl, B., Mintz, T., Nemer, W. E., Tharaux, P. -L., Brousse, V., Andolfo, I., Lamolinara, A., Weinberg, O., Siciliano, A., Norris, P. C., Riley, I. R., Iolascon, A., Serhan, C. N., Brugnara, C., De Franceschi, L. |
| سنة النشر: | 2019 |
| المجموعة: | ARUd'A - Archivio Istituzionale della ricerca dell'università Chieti-Pescara (IRIS) |
| مصطلحات موضوعية: | Defective proresolving response to acute vaso-occlusive events characterizes murine SCD, Treatment with 17R-RvD1 reduces inflammation and vascular dysfunction in SCD mice |
| الوصف: | Resolvins (Rvs), endogenous lipid mediators, play a key role in the resolution of inflammation. Sickle cell disease (SCD), a genetic disorder of hemoglobin, is characterized by inflammatory and vaso-occlusive pathologies. We document altered proresolving events following hypoxia/reperfusion in humanized SCD mice. We demonstrate novel protective actions of 17R-resolvin D1 (17R-RvD1; 7S, 8R, 17R-trihydroxy-4Z, 9E, 11E, 13Z, 15E, 19Z-docosahexaenoic acid) in reducing ex vivo human SCD blood leukocyte recruitment by microvascular endothelial cells and in vivo neutrophil adhesion and transmigration. In SCD mice exposed to hypoxia/reoxygenation, oral administration of 17R-RvD1 reduces systemic/local inflammation and vascular dysfunction in lung and kidney. The mechanism of action of 17R-RvD1 involves (1) enhancement of SCD erythrocytes and polymorphonuclear leukocyte efferocytosis, (2) blunting of NF-kappa B activation, and (3) a reduction in inflammatory cytokines, vascular activation markers, and E-selectin expression. Thus, 17R-RvD1 might represent a new therapeutic strategy for the inflammatory vasculopathy of SCD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/30404812; info:eu-repo/semantics/altIdentifier/wos/WOS:000456614700013; volume:133; issue:3; firstpage:252; lastpage:265; numberofpages:14; journal:BLOOD; https://hdl.handle.net/11564/706052; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85060167521; http://www.bloodjournal.org/content/bloodjournal/133/3/252.full |
| DOI: | 10.1182/blood-2018-07-865378 |
| الاتاحة: | https://hdl.handle.net/11564/706052 https://doi.org/10.1182/blood-2018-07-865378 http://www.bloodjournal.org/content/bloodjournal/133/3/252.full |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F0539E52 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1182/blood-2018-07-865378 |
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